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Volume 3, Issue 4 (Fall 2018)                   jogcr 2018, 3(4): 143-147 | Back to browse issues page


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Parashi S, Astaraei V, Vahdat M, Dini P, Mohammadianamiri M. The Effect of a Single Preoperative Dose of Sublingual Misoprostol in Reducing Intraoperative Blood Loss after Total Abdominal Hysterectomy: A Single-Blind Randomized Controlled Trial. jogcr. 2018; 3 (4) :143-147
URL: http://jogcr.com/article-1-193-en.html
1- Associate Professor of Obstetrics and Gynecology, Akbarabadi Hospital, Iran University of Medical Sciences, Tehran, Iran
2- Resident of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran , vahideh.astaraei@yahoo.com
3- Assistant Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
4- Resident of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
5- Fellowship of Gyneco-oncology, Department of Obstetrics and Gynecology, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences, Tehran, Iran
Abstract:   (151 Views)

Background & Objective: Postoperative hemorrhage is one of the most frequently cited complications of total abdominal hysterectomy (TAH). This study aimed to investigate the effect of a single preoperative dose of sublingual misoprostol on reducing blood loss during total abdominal hysterectomies.
Materials & Methods: This study was a single-blind randomized controlled trial (RCT). The statistical population included all women who were candidates of hysterectomy in 2017 and 2018. A total of 132 patients were randomly selected and classified into two groups of misoprostol (N=66) and placebo (N=66). Examining intraoperative blood loss was considered a primary outcome. Moreover, levels of hemoglobin before and 24 hours after the surgery, the need for a blood transfusion, febrile morbidity, and the duration of hospitalization were regarded as secondary outcomes. The means of bleeding in the two groups were compared using a t-test.
Results: There were no significant differences between the two groups in the baseline characteristics (P<0.05). After the surgery, the mean of hemoglobin values was lower in the placebo group compared to the misoprostol one, and this difference was statistically significant (P<0.001). There was a significant difference in intraoperative blood loss between the two groups, and it was significantly higher in the placebo group (P<0.001).
Conclusion: Taking a single preoperative dose of sublingual misoprostol is effective in reducing intraoperative blood loss after total abdominal hysterectomies. Additionally, this intervention led to a decline in hemoglobin.

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 Taking a single preoperative dose of sublingual misoprostol is effective in reducing intraoperative blood loss after total abdominal hysterectomies. Additionally, this intervention led to a decline in hemoglobin.


Systematic Review: Original Research | Subject: Obstetrics and Gynecology
Received: 2018/03/24 | Accepted: 2018/08/15 | Published: 2018/09/16

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