Write your message
Volume 4, Issue 3 (Summer 2019)                   J Obstet Gynecol Cancer Res 2019, 4(3): 127-130 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hasanzadeh M, Bazmi F, Malakuti P. An Ovarian Mass with Microcystic Stromal Tumor: A Rare Case Report. J Obstet Gynecol Cancer Res. 2019; 4 (3) :127-130
URL: http://jogcr.com/article-1-228-en.html
Abstract:   (833 Views)

Background & Objective: Ovarian microcystic stromal tumor (MST) is a rare subset of ovarian tumors, that usually appears in the form of a pelvic mass which is often unilateral, and has a microcystic realization characterized by small, elliptical, and circular cysts. This microcystic stromal tumor is a type of ovarian insufficiency that has recently come to researchers’ attention. However, no meta-cognitive studies have beem conducted regarding the issue. This tumor morphologically and histologically may look very similar to granulosa cell tumor, Sertoli, Lydic and other ovarian tumors but different characteristic of immunohistochemistry, genetic and gene mutation incidence makes it different. Herein, we report a rare case of the microcystic stromal tumor using immunohistochemistry studies.
Case Report: A 60-year-old woman with ovarian mass referred to gynecology clinic in March 2018. She underwent total abdominal hysterectomy and bilateral Salpingo-oophorectomy. Pathology results showed ovarian microcystic stromal tumor. The patient was fallowed up without any intervention after surgery. To date she is alive with no problem.
Conclusion: Ovarian MST is a rare tumor that originates from the ovarian stroma, which is histologically confused with a number of ovarian tumors, especially metastatic tumors. Immunohistochemistry findings are very helpful in differentiating this tumor from other tumors and preventing diagnostic errors.

Full-Text [PDF 329 kb]   (102 Downloads) |   |   Full-Text (HTML)  (173 Views)  
Systematic Review: Case Report | Subject: Obstetrics and Gynecology
Received: 2019/06/2 | Accepted: 2019/08/29 | Published: 2019/09/27

1. Irving JA, Lee CH, Yip S, Oliva E, McCluggage WG, Young RH. Microcystic Stromal Tumor. The American journal of surgical pathology. 2015 Oct 1;39(10):1420-6. [DOI:10.1097/PAS.0000000000000482] [PMID] [DOI:10.1097/PAS.0000000000000482] [PMID]
2. Irving JA, Young RH. Microcystic stromal tumor of the ovary: report of 16 cases of a hitherto uncharacterized distinctive ovarian neoplasm. The American journal of surgical pathology. 2009 Mar 1;33(3):367-75. [DOI:10.1097/PAS.0b013e31818479c3] [PMID] [DOI:10.1097/PAS.0b013e31818479c3] [PMID]
3. Maeda D, Shibahara J, Sakuma T, Isobe M, Teshima S, Mori M, Oda K, Nakagawa S, Taketani Y, Ishikawa S, Fukayama M. β-catenin (CTNNB1) S33C mutation in ovarian microcystic stromal tumors. The American journal of surgical pathology. 2011 Oct 1;35(10):1429-40. [DOI:10.1097/PAS.0b013e31822d6c71] [PMID] [DOI:10.1097/PAS.0b013e31822d6c71] [PMID]
4. Boyer A, Goff AK, Boerboom D. WNT signaling in ovarian follicle biology and tumorigenesis. Trends in Endocrinology & Metabolism. 2010 Jan 1;21(1):25-32. [DOI:10.1016/j.tem.2009.08.005] [PMID] [DOI:10.1016/j.tem.2009.08.005] [PMID]
5. Yang M, Bhattacharjee MB. Ovarian microcystic stromal tumor: report of a new entity with immunohistochemical and ultrastructural studies. Ultrastructural pathology. 2014 Aug 1;38(4):261-7. [DOI:10.3109/01913123.2014.893045] [PMID] [DOI:10.3109/01913123.2014.893045] [PMID]
6. Reichert RA. Diagnostic gynecologic and obstetric pathology: an atlas and text: Lippincott Williams & Wilkins; 2012.
7. Boerboom D, Paquet M, Hsieh M, Liu J, Jamin SP, Behringer RR, Sirois J, Taketo MM, Richards JS. Misregulated Wnt/β-catenin signaling leads to ovarian granulosa cell tumor development. Cancer research. 2005 Oct 15;65(20):9206-15. [DOI:10.1158/0008-5472.CAN-05-1024] [PMID] [DOI:10.1158/0008-5472.CAN-05-1024] [PMID]
8. Kim MS, Je EM, Choi YJ, Yoo NJ, Lee SH. Mutational and expressional analyses of DICER1 gene in ovarian stromal tumors and other common tumors. AACR; 2013. [DOI:10.1158/1538-7445.AM2013-1921] [PMCID] [DOI:10.1158/1538-7445.AM2013-1921] [PMCID]
9. Kang YN, Cho CH, Kwon SY. Microcystic stromal tumor of the ovary with mutation in exon 3 of β-catenin: a case report. International Journal of Gynecological Pathology. 2015;34(2):121-5. [DOI:10.1097/PGP.0000000000000122] [PMID] [DOI:10.1097/PGP.0000000000000122] [PMID]
10. Kurman J BR, eds. . Pathology of the Female Genital Tract. 6th ed Baltimore: Springer; 2011. [DOI:10.1007/978-1-4419-0489-8] [DOI:10.1007/978-1-4419-0489-8]
11. Jamieson S, Butzow R, Andersson N, Alexiadis M, Unkila-Kallio L, Heikinheimo M, et al. The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary. Modern pathology. 2010;23(11):1477. [DOI:10.1038/modpathol.2010.145] [PMID] [DOI:10.1038/modpathol.2010.145] [PMID]
12. Deshpande V, Oliva E, Young RH. Solid pseudopapillary neoplasm of the ovary: a report of 3 primary ovarian tumors resembling those of the pancreas. The American journal of surgical pathology. 2010;34(10):1514-20. [DOI:10.1097/PAS.0b013e3181f133e9] [PMID] [DOI:10.1097/PAS.0b013e3181f133e9] [PMID]
13. Philip B. Clement , Gennifer N.Stall , Robert H.Young et all. Atlas of Gynecologic Surgical Pathology, Fourth Edition,2008:521-523.

Add your comments about this article : Your username or Email:

Send email to the article author

© 2020 All Rights Reserved | Journal of Obstetrics, Gynecology and Cancer Research (JOGCR)

Designed & Developed by : Yektaweb | Piblisher: Farname Inc.