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Volume 4, Issue 2 (Spring 2019)                   J Obstet Gynecol Cancer Res 2019, 4(2): 81-85 | Back to browse issues page

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Sharifzadeh Mahalati F, Moeini Chaghervand M, Hashemi Dizaji S, Chamani M. Evaluation of the Relationship Between Prenatal Doppler Findings and Hematological Profile in Neonates with Intrauterine Growth Restriction at 32 to 36 Weeks of Gestation. J Obstet Gynecol Cancer Res. 2019; 4 (2) :81-85
URL: http://jogcr.com/article-1-239-en.html
1- Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran , Mina.moeini6548@yahoo.com
Abstract:   (391 Views)

Background & Objective: Neonates with birth weights below the 10th percentile of gestational age- and sex-specific reference are known as neonates with intrauterine growth restriction (IUGR). Neonates with IUGR are more prone to diseases, infections, respiratory failure, and neonatal mortality. This study aimed to evaluate the association between perinatal Doppler findings and hematological indices in neonates with intrauterine growth restriction at gestational ages of 32 to 36 weeks.
Materials & Methods: In this analytical cross-sectional study conducted at Akbarabadi Hospital from 2016 to 2017, 90 neonates with IUGR who underwent umbilical artery Doppler ultrasound during pregnancy were haphazardly selected and the umbilical artery Doppler velocity was compared with neonatal hematological indices.
Results: Results indicated that 48, 25, and 17 neonates had normal, absent, and reverse Doppler, respectively. A decreased umbilical artery Doppler velocity was associated with a reduction in platelet level (P=0.004) and an increase in NRBC level (P=0.002). Considering a P-value>0.05, white blood cell and hemoglobin levels had no associations with umbilical artery Doppler. However, IVH was correlated with the severity of abnormal umbilical artery Doppler (P=0.001). There was no significant relationship between hyperbilirubinemia and abnormal umbilical artery Doppler (P<0.05).
Conclusion: The severity of thrombocytopenia and the level of NRBC in IUGR neonates are directly related to abnormal umbilical artery Doppler and consequently, chronic hypoxia in these neonates. Furthermore, IVH is more likely to occur in neonates with chronic hypoxia. Early and perinatal diagnoses of these abnormalities can help us treat them faster and reduce long-term morbidities.

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The severity of thrombocytopenia and the level of NRBC in IUGR neonates are directly related to abnormal umbilical artery Doppler and consequently, chronic hypoxia in these neonates. Furthermore, IVH is more likely to occur in neonates with chronic hypoxia. Early and perinatal diagnoses of these abnormalities can help us treat them faster and reduce long-term morbidities.


Systematic Review: Original Research | Subject: Maternal Fetal Medicine
Received: 2018/08/12 | Accepted: 2019/05/3 | Published: 2019/09/16

References
1. Alexander GR, Wingate MS, Mor J, Boulet S. Birth outcomes of Asian-Indian-Americans. Int J Gynaecol Obstet. 2007 Jun; 97(3). pp: 215-20. [DOI:10.1016/j.ijgo.2007.02.017] [PMID] [DOI:10.1016/j.ijgo.2007.02.017] [PMID]
2. Kramer MS, Barros FC, Demissie K, Liu S, Kiely J, Joseph KS. Does reducing infant mortality depend on preventing low birth weight? An analysis of temporal trends in the Americas.Paediatr Perinat Epidemiol. 2005 Nov. 19(6). pp: 445-51. [DOI:10.1111/j.1365-3016.2005.00681.x] [PMID] [DOI:10.1111/j.1365-3016.2005.00681.x] [PMID]
3. Mansour E, Eissa AN, Nofal LM, Kharboush I, Reda AA. Morbidity and mortality of low-birth-weight infants in Egypt. East Mediterr Health J. 2005 Jul. 11(4). pp: 723-31.
4. Hoffman MC, Jeffers S, Carter J, Duthely L, Cotter A, Gonzalez-Quintero VH. Pregnancy at or beyond age 40 years is associated with an increased risk of fetal death and other adverse outcomes. Am J Obstet Gynecol. 2007 May.196 (5). pp: e11-3. [DOI:10.1016/j.ajog.2006.10.862] [PMID] [DOI:10.1016/j.ajog.2006.10.862] [PMID]
5. Patricia HC, Andrew MT, Chest circumference as an indicator of intrauterine growth retardation. Early Human development 2010; 44; 161-67 [DOI:10.1016/0378-3782(95)01705-4] [DOI:10.1016/0378-3782(95)01705-4]
6. John LK, Kate MB, Stella YU. Low birth weight and intrauterine growth retardation, birth outcomes CDCS public health surveillance for women, infants and children 2005. Available at www.google.com
7. Sharon D, Gilberto FC. Associations of intrauterine growth restriction among term infants and maternal pregnancy intended ness, initial happiness about being pregnant and sense of control, pediatrics 2003, available at www.google.com
8. Cunningham FG. Cesarean section and postpartum hysterectomy. Williams obstetrics. 2001.
9. Baschat AA, Kush M, Berg C, Gembruch U, Nicolaides KH, Harman CR, Turan OM. Hematologic profile of neonates with growth restriction is associated with rate and degree of prenatal Doppler deterioration. Ultrasound in Obstetrics & Gynecology. 2013 Jan;41(1):66-72. [DOI:10.1002/uog.12322] [PMID] [DOI:10.1002/uog.12322] [PMID]
10. Baschat AA, Gembruch U, Reiss I, Gortner L. Neonatal nucleated red blood cell counts in growth restricted fetuses: relationship to arterial and venous Doppler studies. Am J Obstet Gynecol. 1999 Jul; 181(1): 190-5 [DOI:10.1016/S0002-9378(99)70458-8] [DOI:10.1016/S0002-9378(99)70458-8]
11. Turan S, Turan OM, Salim M. Cardiovascular transition to extrauterine life in growth restricted neonates: relashionship with prenatal Doppler findings. Fetal diagn Ther. 2013; 33(2): 103-109. [DOI:10.1159/000345092] [PMID] [DOI:10.1159/000345092] [PMID]
12. Martinelli S, Francisco RP, Bittar RE, Zugaib M. Hematological indices at birth in relation to arterial and venous Doppler in small‐for‐gestational‐age fetuses. Acta obstetricia et gynecologica Scandinavica. 2009 Aug 1;88(8):888-93. [DOI:10.1080/00016340903090985] [PMID] [DOI:10.1080/00016340903090985] [PMID]
13. Hidehiko M, Masako S, Yoichi K. Thrombocytopenia in preterm Infants with intrauterine Growth Restriction. Acta Med. Okayama, 2008 june; 62(5) : 313-317.
14. Hidehiko M, Masako S, Yoichi K. Thrombocytopenia in preterm Infants with intrauterine Growth Restriction. Acta Med. Okayama, 2008 june; 62(5) : 313-317.
15. Monica G. Hasmasanu S.Neonatal short term outcom in infants with intra uterine growth restriction. 2015 Aug; 36(8): 974-953. [DOI:10.15537/smj.2015.8.11533] [PMID] [PMCID] [DOI:10.15537/smj.2015.8.11533] [PMID] [PMCID]

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