Write your message
Volume 5, Issue 1 (Winter 2020)                   J Obstet Gynecol Cancer Res 2020, 5(1): 19-23 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Arian A, Giti M, Moosavi A, Akhavan S, Azhideh A, Arab-Ahmadi M. Magnetic Resonance Imaging (MRI) Staging in Women with Endometrial Cancer: A Correlation with Histopathology. J Obstet Gynecol Cancer Res. 2020; 5 (1) :19-23
URL: http://jogcr.com/article-1-255-en.html
1- Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
2- Gynecologist Oncologist, Tehran University of Medical Science, Iran
3- Gynecology Ward, Vali-e Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran , setare_akh@yahoo.com
4- Radiology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (395 Views)

Background & Objective: Endometrial cancer is the most frequent genitourinary tract malignancy in women. Women with endometrial cancer mostly refer at early stages of the disease which leads to good prognosis. Magnetic resonance imaging (MRI) has a crucial role in staging of the cancer. As there are little studies regarding the correlation between histopathology and International Federation of Gynecology and Obstetrics (FIGO) staging in Iranian women with endometrial cancer, we designed this study to assess the relationship between histopathology and FIGO staging with MRI in Iranian women with endometrial cancer.

Materials & Methods: This retrospective study was conducted in Imam Khomeini hospital complex between January 2015 and January 2018. All MRIs were performed on a 3T system. All imaging was done in Imam Hospital under observation of attending Radiologists with 10 and 20 years of work experience in women’s imaging who conducted this research. Obtained surgical specimens were assessed by an expert pathologist in the field of cancer and type of cancers were determined.

Results: Thirty two women with proved endometrial cancer (D&C or endometrial biopsy) were enrolled. Mean age was 55.2±10.7 years and all women referred to our clinic with vaginal bleeding. The most common FIGO staging was IA (14, 43.75%) and the most frequent pathology was endometrioid type adenocarcinoma (30, 93.7%) (60% well differentiated, 13.3% moderately differentiated, and 26.6% poorly differentiated). Most cases with endometrioid type poorly differentiated referred with IIIC1 stage of cancer, most patients with endometrioid type well differentiated referred with stage IA, a patient with clear cell cancer referred with stage IIIB, and patients with sarcoma referred with stages IB, and IV.

Conclusion:  Patients with poor differentiated endometrial cancer referred with higher stages of the cancer.

Full-Text [PDF 259 kb]   (180 Downloads) |   |   Full-Text (HTML)  (83 Views)  
Systematic Review: Original Research | Subject: Gynecology Oncology
Received: 2020/02/16 | Accepted: 2020/06/27 | Published: 2020/07/20

References
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer J Clinic. 2018;68(6):394-424. [DOI:10.3322/caac.21492] [PMID]
2. Allard JE, Maxwell GL. Race disparities between black and white women in the incidence, treatment, and prognosis of endometrial cancer. Cancer Control. 2009;16(1):53-6. [DOI:10.1177/107327480901600108] [PMID]
3. Aryan A, Askari F, Mohammadifar M, Ghajarzadeh M. Role of MRI (Magnetic Resonance Imaging) in Preoperative Staging of Endometrial Cancer: A Review. Austin J Radiol. 2016;3(1):1045.
4. Voskuil DW, Monninkhof EM, Elias SG, Vlems FA, van Leeuwen FE. Physical activity and endometrial cancer risk, a systematic review of current evidence. Cancer Epidemiol Prevent Biomark. 2007;16(4):639-48. [DOI:10.1158/1055-9965.EPI-06-0742] [PMID]
5. Carcangiu ML eaeTotfroIKP, Sobin, LH eWccotIL.
6. Lax SF. Pathology of Endometrial Carcinoma. Advances in experimental medicine and biology. 2017;943:75-96. [DOI:10.1007/978-3-319-43139-0_3] [PMID]
7. Sheets: NCICSF, sorpus and uterus NB, Md: National, Cancer Institute.
8. Freeman SJ, Aly AM, Kataoka MY, Addley HC, Reinhold C, Sala E. The revised FIGO staging system for uterine malignancies: implications for MR imaging. Radiographics. 2012;32(6):1805-27. [DOI:10.1148/rg.326125519] [PMID]
9. Arian A, Ghanbari Z, Deldar Pasikhani M, Eftekhar T, Gity M, Shakiba M, Sabetrasekh P, Setayeshpour B, Alipour A. Agreement of manual exam (POP-Q) with pelvic MRI in assessment of anterior pelvic organ prolapse. Iran J Radiol. 2017 Oct 1;14(4):e38542. [DOI:10.5812/iranjradiol.38542]
10. Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I. Endometrial cancer. The Lancet. 2005;366(9484):491-505. [DOI:10.1016/S0140-6736(05)67063-8]
11. Lien H, Blomlie V, Trope C, Kaern J, Abeler V. Cancer of the endometrium: value of MR imaging in determining depth of invasion into the myometrium. AJR American journal of roentgenology. 1991;157(6):1221-3. [DOI:10.2214/ajr.157.6.1950869] [PMID]
12. Marti-Bonmati L, Graells M, Ronchera-Oms C. Reduction of peristaltic artifacts on magnetic resonance imaging of the abdomen: a comparative evaluation of three drugs. Abdominal Imaging. 1996;21(4):309-13. [DOI:10.1007/s002619900070] [PMID]
13. Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. No longer published by Elsevier; 2009. [DOI:10.1016/j.ijgo.2009.02.012] [PMID]
14. Tanaka T, Terai Y, Ono YJ, Fujiwara S, Tanaka Y, Sasaki H, et al. Preoperative MRI and intraoperative frozen section diagnosis of myometrial invasion in patients with endometrial cancer. Int J Gynecol Cancer. 2015;25(5):879-83. [DOI:10.1097/IGC.0000000000000470] [PMID]
15. Zamani F, Goodarzi S, Hallaji F, Zamiri A, Deilami T, Malek M, et al. Diagnostic value of pelvic MRI for assessment of the depth of myometrial invasion and cervical involvement in endometrial cancer: comparison of new versus old FIGO staging. Iran J Radiol. 2012;9(4):202. [DOI:10.5812/iranjradiol.5276] [PMID] [PMCID]
16. Wu T-I, Yen T-C, Lai C-H. Clinical presentation and diagnosis of uterine sarcoma, including imaging. Best Practice Res Clin Obstet Gynaecol. 2011;25(6):681-9. [DOI:10.1016/j.bpobgyn.2011.07.002] [PMID]
17. Vitale SG, Valenti G, Gulino FA, Cignini P, Biondi A. Surgical treatment of high stage endometrial cancer: current perspectives. Updates Surg. 2016;68(2):149-54. [DOI:10.1007/s13304-015-0340-1] [PMID]
18. Schmandt RE, Iglesias DA, Co NN, Lu KH. Understanding obesity and endometrial cancer risk: opportunities for prevention. Am J Obstet Gynecol. 2011 Dec 1;205(6):518-25. [DOI:10.1016/j.ajog.2011.05.042] [PMID] [PMCID]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2020 All Rights Reserved | Journal of Obstetrics, Gynecology and Cancer Research (JOGCR)

Designed & Developed by : Yektaweb | Piblisher: Farname Inc.