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Fri, Jan 15, 2021
[Archive]
Volume 5, Issue 2 (Spring 2020)
J Obstet Gynecol Cancer Res 2020, 5(2): 39-43 |
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Rezaei Z, Adabi K, Sadjadi A. A Comparison of Endometrial Thickness and Pregnancy Outcomes in Two Methods of Intrauterine Injection and Subcutaneous Injection of GCSF in Infertile Women Candidates for IVF. J Obstet Gynecol Cancer Res. 2020; 5 (2) :39-43
URL: http://jogcr.com/article-1-275-en.html
URL: http://jogcr.com/article-1-275-en.html
1- Department of Obstetrics and Gynecology, Yas Women General Hospital, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Obstetrics and Gynecology, Yas Women General Hospital, Tehran University of Medical Sciences, Tehran, Iran , adeleh.sadjadi@gmail.com
2- Department of Obstetrics and Gynecology, Yas Women General Hospital, Tehran University of Medical Sciences, Tehran, Iran , adeleh.sadjadi@gmail.com
Abstract: (295 Views)
Background & Objective: An endometrial thickness of less than 7 mm adversely affects pregnancy outcomes. There is also ample evidence of the impact of granulocyte colony-stimulating factor (G-CSF) on treatment-resistant thin endometrium. Therefore, this study compares the effects of intrauterine and subcutaneous injections of G-CSF on increasing endometrial thickness (ET) and pregnancy outcomes in infertile women who were candidates for in vitro fertilization (IVF).
Materials & Methods: In the current randomized, double-blind clinical trial, 34 patients with a history of failed IVF cycles and treatment-resistant thin endometrium were randomized into two routes of G-CSF injection, i.e., intrauterine and subcutaneous, by using a random number table method. Outcomes including ET and chemical and clinical pregnancy rates were compared in two groups.
Results: ET increased significantly in both groups after G-CSF administration (intrauterine and subcutaneous); however, this increase in thickness was significantly greater in the intrauterine injection group than in the subcutaneous injection group. Pregnancy outcomes were similar in two groups. Drug side effects were significantly lower in the intrauterine injection group than in the subcutaneous injection group.
Conclusion: G-CSF can significantly increase ET in cases of repeated IVF failure, and intrauterine injection of this drug was more effective than subcutaneous injection.
Materials & Methods: In the current randomized, double-blind clinical trial, 34 patients with a history of failed IVF cycles and treatment-resistant thin endometrium were randomized into two routes of G-CSF injection, i.e., intrauterine and subcutaneous, by using a random number table method. Outcomes including ET and chemical and clinical pregnancy rates were compared in two groups.
Results: ET increased significantly in both groups after G-CSF administration (intrauterine and subcutaneous); however, this increase in thickness was significantly greater in the intrauterine injection group than in the subcutaneous injection group. Pregnancy outcomes were similar in two groups. Drug side effects were significantly lower in the intrauterine injection group than in the subcutaneous injection group.
Conclusion: G-CSF can significantly increase ET in cases of repeated IVF failure, and intrauterine injection of this drug was more effective than subcutaneous injection.
Keywords: |Treatment-resistant thin endometrium|GCSF|IVF ,
Systematic Review: Original Research |
Subject:
Obstetrics and Gynecology
Received: 2020/08/26 | Accepted: 2020/09/13 | Published: 2020/10/19
Received: 2020/08/26 | Accepted: 2020/09/13 | Published: 2020/10/19
References
1. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015;13:37. Published 2015 Apr 26. [DOI:10.1186/s12958-015-0032-1] [PMID] [PMCID]
2. Petropanagos A, Cattapan A, Baylis F, Leader A. Social egg freezing: risk, benefits and other considerations. CMAJ. 2015;187(9):666-669. [DOI:10.1503/cmaj.141605] [PMID] [PMCID]
3. Spitzer D, Haidbauer R, Corn C, Stadler J, Wirleitner B, Zech NH. Effects of embryo transfer quality on pregnancy and live birth delivery rates. J Assist Reprod Genet. 2012;29(2):131-135. [DOI:10.1007/s10815-011-9680-z] [PMID] [PMCID]
4. Broekmans FJ, Kwee J, Hendriks DJ, Mol BW, Lambalk CB. A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update. 2006; 12(6): 685-718. doi:10.1093/humupd/dml034 [DOI:10.1093/humupd/dml034] [PMID]
5. Al-Ghamdi A, Coskun S, Al-Hassan S, Al-Rejjal R, Awartani K. The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome. Reprod Biol Endocrinol. 2008; 6: 37. Published 2008 Sep 2. doi: 10.1186/1477-7827-6-37 [DOI:10.1186/1477-7827-6-37] [PMID] [PMCID]
6. Isaacs JD Jr, Wells CS, Williams DB, Odem RR, Gast MJ, Strickler RC. Endometrial thickness is a valid monitoring parameter in cycles of ovulation induction with menotropins alone. Fertil Steril. 1996; 65(2): 262-266. doi: 10.1016/s0015-0282(16)58082-0 [DOI:10.1016/S0015-0282(16)58082-0]
7. Sharkey A. Cytokines and implantation. Rev Reprod. 1998; 3(1): 52-61. [DOI:10.1530/ror.0.0030052] [PMID]
8. Psychoyos A. Uterine receptivity for nidation. Ann N Y Acad Sci. 1986; 476: 36-42. [DOI:10.1111/j.1749-6632.1986.tb20920.x] [PMID]
9. Barash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003; 79(6): 1317-1322. [DOI:10.1016/S0015-0282(03)00345-5]
10. Gleicher N, Kim A, Michaeli T, Lee HJ, Shohat-Tal A, Lazzaroni E, Barad DH. A pilot cohort study of granulocyte colony-stimulating factor in the treatment of unresponsive thin endometrium resistant to standard therapies. Hum Reprod. 2013; 28(1): 172-177. [DOI:10.1093/humrep/des370] [PMID]
11. Gleicher N, Vidali A, Barad DH. Successful treatment of unresponsive thin endometrium. Fertil Steril. 2011; 95(6): 2123.e13-2123.e2.123E17. [DOI:10.1016/j.fertnstert.2011.01.143] [PMID]
12. Dale DC, Cottle TE, Fier CJ, Bolyard AA, Bonilla MA, Boxer LA, et al. Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry. Am J Hematol. 2003; 72(2): 82-93. [DOI:10.1002/ajh.10255] [PMID]
13. Clark DA. Is there any evidence for immunologically mediated or immunologically modifiable early pregnancy failure? J Assist Reprod Genet. 2003; 20(2): 63-72. [DOI:10.1023/A:1021788024214] [PMID] [PMCID]
14. Narahara H, Mine S, Kawano Y, Johnston JM, Miyakawa I. Effects of colony-stimulating factors on the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages. Am J Obstet Gynecol. 2003; 188(1): 157-161. [DOI:10.1067/mob.2003.106] [PMID]
15. Yanagi K, Makinoda S, Fujii R, et al. Cyclic changes of granulocyte colony-stimulating factor (G-CSF) mRNA in the human follicle during the normal menstrual cycle and immunolocalization of G-CSF protein. Hum Reprod. 2002; 17(12): 3046-3052. [DOI:10.1093/humrep/17.12.3046] [PMID]
16. Salmassi A, Schmutzler AG, Huang L, Hedderich J, Jonat W, Mettler L. Detection of granulocyte colony-stimulating factor and its receptor in human follicular luteinized granulosa cells. Fertil Steril. 2004; 81 Suppl 1: 786-791. [DOI:10.1016/j.fertnstert.2003.09.039] [PMID]
17. Zhang Z, Fang Q, Wang J. Involvement of macrophage colony-stimulating factor (M-CSF) in the function of follicular granulosa cells. Fertil Steril. 2008; 90(3): 749-754. [DOI:10.1016/j.fertnstert.2007.06.098] [PMID]
18. Takasaki A, Ohba T, Okamura Y, Honda R, Seki M, Tanaka N, Okamura H. Clinical use of colony-stimulating factor-1 in ovulation induction for poor responders. Fertil Steril. 2008; 90(6): 2287-2290. [DOI:10.1016/j.fertnstert.2007.10.043] [PMID]
19. Scarpellini F, Sbracia M. Use of granulocyte colony-stimulating factor for the treatment of unexplained recurrent miscarriage: a randomised controlled trial. Hum Reprod. 2009; 24(11): 2703-2708. [DOI:10.1093/humrep/dep240] [PMID]
20. Jensen JR, Witz CA, Schenken RS, Tekmal RR. A potential role for colony-stimulating factor 1 in the genesis of the early endometriotic lesion. Fertil Steril. 2010; 93(1): 251-256. 18. Dieckgraefe BK, Korzenik JR. Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet. 2002; 360(9344): 1478-1480. [DOI:10.1016/S0140-6736(02)11437-1]
21. Dieckgraefe BK, Korzenik JR. Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet. 2002; 360(9344): 1478-1480. [DOI:10.1016/S0140-6736(02)11437-1]
22. Lédée N, Lombroso R, Lombardelli L, Selva J, Dubanchet S, Chaouat G, et al. Cytokines and chemokines in follicular fluids and potential of the corresponding embryo: the role of granulocyte colony-stimulating factor. Hum Reprod. 2008; 23(9): 2001-2009. [DOI:10.1093/humrep/den192] [PMID]
23. Salmassi A, Schmutzler AG, Schaefer S, Koch K, Hedderich J, Jonat W, Mettler L. Is granulocyte colony-stimulating factor level predictive for human IVF outcome? Hum Reprod. 2005; 20(9): 2434-2440. [DOI:10.1093/humrep/dei071] [PMID]
24. Barad DH, Yu Y, Kushnir VA, Shohat-Tal A, Lazzaroni E, Lee HJ, Gleicher N. A randomized clinical trial of endometrial perfusion with granulocyte colony-stimulating factor in in vitro fertilization cycles: impact on endometrial thickness and clinical pregnancy rates. Fertil Steril. 2014; 101(3): 710-715. [DOI:10.1016/j.fertnstert.2013.12.016] [PMID]
25. Eftekhar M, Sayadi M, Arabjahvani F. Transvaginal perfusion of G-CSF for infertile women with thin endometrium in frozen ET program: A non-randomized clinical trial. Iran J Reprod Med. 2014; 12(10): 661-666.
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