Iranian Society of Gynecology Oncology

Authors

Kashan University of Medical Sciences, Kashan, Iran

Abstract

Introduction: Although 1% to 2% of all pregnancies are ectopic, ectopic pregnancy (EP) is the most frequent obstetrical disease leads to maternal mortality and morbidity at first trimester. The basic diagnostic method of EP is the human chorionic gonadotropin (HCG) test and transvaginal ultrasound. There are some rare EP cases with negative HCG blood test.
Case presentation: A 31-years old woman referred to the emergency department with hypogastric, periumbilical, and right upper quadrant intermittent pain and vaginal bleeding and prior history of EP 7-months ago that treated with methotrexate and her intra uterine device had been removed at that time. Her last menstrual period was undetermined. Although HCG blood test-qualitative was negative (2.08 IU /ml),ultrasound examination showed an 43×53 mm echogenic, heterogenic complex solid mass in the left adnexa and a large amount of echogenic fluid demonstrating hemoperitoneum. Taken surgery because of the exceeded abdominal pain revealed active bleeding in the left salpinx due to ruptured EP.
Conclusion: Management of patients suspected of EP with negative HCG-blood test is difficult. In this uncommon cases in emergency, computed tomography, ultrasound and diagnostic laparoscopy or laparotomy can improve prognosis of patient.
 

Keywords

  1. 1. Van Den Eeden SK, Shan J, Bruce C, Glasser M. Ectopic pregnancy rate and treatment utilization in a large managed care organization. Obstetrics and gynecology. 2005;105(5 Pt 1):1052-7. 2. Murray H, Baakdah H, Bardell T, Tulandi T. Diagnosis and treatment of ectopic pregnancy. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2005;173(8):905-12. 3. Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M. Maternal age and fetal loss: population based register linkage study. BMJ (Clinical research ed). 2000;320(7251):1708-12. 4. Stenman U-H, Tiitinen A, Alfthan H, Valmu L. The classification, functions and clinical use of different isoforms of HCG. Human Reproduction Update. 2006;12(6):769-84. 5. Johnson S, Eapen S, Smith P, Warren G, Zinaman M. Significance of pregnancy test false negative results due to elevated levels of β-core fragment HCG. Journal of immunoassay & immunochemistry. 2017;38(4):449-55. 6. Brennan DF, Kwatra S, Kelly M, Dunn M. Chronic ectopic pregnancy--two cases of acute rupture despite negative beta HCG. The Journal of emergency medicine. 2000;19(3):249-54. 7. Sheele JM, Bernstein R, Counselman FL. A Ruptured Ectopic Pregnancy Presenting with a Negative Urine Pregnancy Test. Case reports in emergency medicine. 2016;2016:7154713. 8. Gronowski AM, Cervinski M, Stenman UH, Woodworth A, Ashby L, Scott MG. False-negative results in point-of-care qualitative human chorionic gonadotropin (HCG) devices due to excess HCGbeta core fragment. Clinical chemistry. 2009;55(7):1389-94. 9. Nerenz RD, Song H, Gronowski AM. Screening method to evaluate point-of-care human chorionic gonadotropin (HCG) devices for susceptibility to the hook effect by HCG β core fragment: evaluation of 11 devices. Clinical chemistry. 2014;60(4):667-74. 10. Nerenz RD, Butch AW, Ashby L, Woldemariam GA, Gronowski AM. Evaluation of a semi-quantitative pregnancy device for susceptibility to interference caused by HCGβcf. Clinical biochemistry. 2015;48(12):815-7.