Comparison Between the Effects of Fentanyl Versus Remifentanil on ICSI Regarding Pregnancy Outcomes

Anmar Burhan, Shams; Ghazi Reshan, Raed; El Refaeey, Abdelaziz; M. Abou-El-Naga, Amoura

doi:10.30699/jogcr.9.2.218

Document Type : Original Research Article

Authors

¹ Department of Applied Embryology, Institute of Infertility and Assisted Reproductive Techniques, Al-Nahrian University, Al-Nahrain, Iraq

² Department of Anesthesia, Institute of Infertility and Assisted Reproductive Techniques, Al-Nahrain University, Al-Nahrain, Iraq

³ Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

⁴ Department of Experimental Embryology Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt

https://doi.org/10.30699/jogcr.9.2.218

Abstract

Background & Objective: The presence of anesthetic drugs in the serum with potential negative effects on hormone concentration and pregnancy rate has been shown in a number of human research. To assess the effects on blood hormone concentration and pregnancy rate of two different medications (remifentanil vs. fentanyl) used for general anesthesia during oocyte retrieval.
Materials & Methods: the present prospective comparative study was conducted at Iraq's "High Institute of Infertility Diagnosis and Assisted Reproductive Technologies/Al-Nahrain University/Baghdad/Iraq" infertility center and was approved by Mansoura University for its validity. Sixty infertile women who were having (ICSI) for a range of infertility-related reasons that entered the study. The women's ages varied from 20 to 45 years. The study's length was extended from September 2022 to September 2023. According to the general anesthetic protocol for oocyte retrieval, those patients were divided into two groups. Midazolam, propofol, and fentanyl were given to the group one, while remifentanil, midazolam, and propofol were given to the group two.
Results: Compare the hormone levels before and after fentanyl anesthesia. The current study's findings indicated that remifentanil led to a greater pregnancy rate (40.0%) than fentanyl (36.7%). According to the results, there were significantly higher LH levels after fentanyl anesthesia (P = 0.014). However, insignificantly higher FSH (P = 0.481) and prolactin (P = 0.076) levels post-fentanyl anesthesia. Also, significantly higher LH levels after remifentanil anesthesia (P = 0.046), insignificantly higher FSH levels (P = 0.383) and prolactin levels (P = 0.16) after remifentanil anesthesia. In the fentanyl group, the recovery time was substantially longer (P<0.001).
Conclusion: Because of its quicker recovery time and much greater pregnancy rate, remifentanil is preferred over fentanyl in normal general anesthetic treatments for egg harvest in ICSI operations.

Keywords

Main Subjects

General Gynecology and Pelvic Floor

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Journal of Obstetrics, Gynecology and Cancer Research

Comparison Between the Effects of Fentanyl Versus Remifentanil on ICSI Regarding Pregnancy Outcomes

References

References

Volume 9, Issue 2 - Serial Number 37
March and April 2024
Pages 218-224

Comparison Between the Effects of Fentanyl Versus Remifentanil on ICSI Regarding Pregnancy Outcomes

References

References

Volume 9, Issue 2 - Serial Number 37March and April 2024Pages 218-224

Volume 9, Issue 2 - Serial Number 37
March and April 2024
Pages 218-224