Document Type : Systematic Review Article

Authors

• Achmad Kemal Harzif ¹
• Mila Maidarti ²
• Costan Tryono Parulian Rumapea ³
• Sarah Miriam Ratna Pratamasari ³
• Heidi Dewi Mutia ⁴
• Nafi’atul Ummah ⁴
• Aisyah Retno Puspawardani ⁴
• Putri Nurbaeti ⁴
• Budi Wiweko ²

¹ Division of Immuno-Endocrinology and Fertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesi

² Division of Immuno-Endocrinology and Fertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia

³ Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia

⁴ Indonesian Reproductive Medicine Research and Training Center (INA- REPROMED) Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital Jakarta, Indonesia

Abstract

Abstract:

Background and Objective: Endometriosis is one of the primary etiology of subfertility in women; in severe cases, endometriosis surgery could result in infertility due to oophorectomy. Ovarian tissue cryopreservation is a method by which the ovarian cortex is frozen and retransplanted in patients. This method is unaffected by the menstrual cycle, can restore ovarian hormonal function, and does not require sperm donor or ovulation induction. This systematic review aims to review the utility of ovarian tissue cryopreservation in endometriosis patients.



Methods: We searched the literature using keywords such as “fertility preservation,” “cryopreservation,” “endometriosis,” and “ovarian tissue cryopreservation” for relevant articles in Pubmed and Embase. We included all relevant articles, including case reports, cohort studies, and clinical trials.



Results: A total of 6 articles were included in this systematic review, including three retrospective studies and three case reports. In screening for candidates of ovarian tissue cryopreservation, serum antimullerian hormone (AMH) is a good marker for primordial follicle count. Patients undergoing ovarian tissue implantation after cryopreservation demonstrated an excellent pregnancy rate (41.2%) in one study. Follicle viability and hormonal function were preserved post-transplantation.



Conclusion: The current evidence shows that endocrine function and fertility in patients grafted with cryopreserved ovarian tissue are good. However, the evidence on the long-term outcome of ovarian tissue cryopreservation in endometriosis patients is lacking.

Keywords

• Keywords: assisted reproductive technique
• endometriosis
• fertility preservation
• ovarian tissue cryopreservation

Main Subjects

• Reproductive Medicine