:: Volume 3, Issue 1 (2-2018) ::
jogcr 2018, 3(1): 1-7 Back to browse issues page
Effects of Estrogen and Progesterone on Catalepsy and Motor and Balance Impairment Classified as Haloperidol-induced Extrapyramidal Disorders
Mohammadmahdi Sabahi 1, Sara Amiahmadi 1, Rasool Haddadi * 2
1- Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Pharmacology, Hamadan University of medical sciences, Hamadan, Iran.
Abstract:   (162 Views)
Aims Various evidences have shown the effect of ovarian hormones on locomotor activities and catalepsy induced by a variety of stimuli. The aim of this study was to evaluate the effects of estrogen and progesterone on catalepsy and motor and balance impairment classified as haloperidol-induced extrapyramidal disorders.
Materials and Methods The current experimental study was performed on 96 female Wistar rats (180-200g). These rats were randomly divided into 16 groups (n=6). Prior to administration of haloperidol, the rats were pretreated with flutamide (10mg/kg, i.p.), estrogen (1mg/kg 17 β-estradiol, s.c.), and/or progesterone (1mg/kg, i.p.) for 1 day or 7 consecutive days. The effects of estrogen and progesterone on haloperidol-induced catalepsy and motor impairment were assessed by a bar test and a rotarod performance test, respectively. Data were analyzed by SPSS 22 software using ANCOVA and Tukey test.
Findings One to 7-day treatment with estrogen had a protective effect on haloperidol-induced extrapyramidal disorders such that it significantly improved catalepsy and motor impairment in the rats and restored and normalized their motor levels. However, the progesterone administration did not represent significant effects in improving extrapyramidal symptoms and a slight improvement was achieved. The co-administration of flutamide significantly reduced the protective effect of estrogen on catalepsy and motor balance impairment induced by haloperidol.
Conclusion The deficiency of ovarian hormones increases catalepsy; however, this disorder is more likely to occur due to estrogen insufficiency. Hence, progesterone plays a little role in it. Moreover, the anti-cataleptic effect of ovarian hormones is exerted through affecting androgenic receptors.
Keywords: Parkinson’s disease, Estrogen, Progesterone, Haloperidol, Catalepsy, Rotarod Test
Full-Text [PDF 892 kb]   (59 Downloads)    
Article Type: Original Research | Subject: Special
Received: 2018/04/16 | Accepted: 2018/06/20 | Published: 2018/07/16



XML     Print



Volume 3, Issue 1 (2-2018) Back to browse issues page