Journal of Obstetrics, Gynecology and Cancer Research

Published by: Kowsar

Genital Warts

Authors Information
1 Gynecology Oncology Department, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
2 General Surgery Department, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Article Notes and Dates
Journal of Obstetrics, Gynecology and Cancer Research: February 2017, 2 (1); e11440.Published Online: February 26, 2017
Article Type: Review Article; Received : March 1, 2017; Accepted : March 19, 2017

To Cite : Akhavan S, Mousavi A, Modaresgilani M, Alibakhshi A. Genital Warts, J Obstet Gynecol Cancer Res. 2017 ;2(1):e11440. doi: 10.5812/ogcr.11440.

Copyright: Copyright © 2017, Journal of Obstetrics, Gynecology and Cancer Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Transmission Method
3. HPV Types
4. Detection Method
5. Differential Diagnosis
6. Diagnosis
7. Warts in Pregnancy
8. Management of Genital Warts
9. Follow-Up Care after Treatment
  • 1. Fleischer AB Jr, Parrish CA, Glenn R, Feldman SR. Condylomata acuminata (genital warts): patient demographics and treating physicians. Sex Transm Dis. 2001; 28(11): 643-7[PubMed]
  • 2. Garland SM, Steben M, Sings HL, James M, Lu S, Railkar R, et al. Natural history of genital warts: analysis of the placebo arm of 2 randomized phase III trials of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine. J Infect Dis. 2009; 199(6): 805-14[DOI][PubMed]
  • 3. Oriel JD. Natural history of genital warts. Br J Vener Dis. 1971; 47(1): 1-13[PubMed]
  • 4. Padel AF, Venning VA, Evans MF, Quantrill AM, Fleming KA. Human papillomaviruses in anogenital warts in children: typing by in situ hybridisation. BMJ. 1990; 300(6738): 1491-4[PubMed]
  • 5. Gissmann L, Wolnik L, Ikenberg H, Koldovsky U, Schnurch HG, zur Hausen H. Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proc Natl Acad Sci U S A. 1983; 80(2): 560-3[PubMed]
  • 6. Stanley M. Prophylactic HPV vaccines: prospects for eliminating ano-genital cancer. Br J Cancer. 2007; 96(9): 1320-3[DOI][PubMed]
  • 7. Stanley M. Pathology and epidemiology of HPV infection in females. Gynecol Oncol. 2010; 117(2 Suppl)-10[DOI][PubMed]
  • 8. Sexually Transmitted Diseases Treatment Guidelines. Morb Mortal Wkly Rep. 2010; 59: 69-74
  • 9. Kodner CM, Nasraty S. Management of genital warts. Am Fam Physician. 2004; 70(12): 2335-42[PubMed]
  • 10. Forcier M, Musacchio N. An overview of human papillomavirus infection for the dermatologist: disease, diagnosis, management, and prevention. Dermatol Ther. 2010; 23(5): 458-76[DOI][PubMed]
  • 11. Osborne NG, Adelson MD. Herpes simplex and human papillomavirus genital infections: controversy over obstetric management. Clin Obstet Gynecol. 1990; 33(4): 801-11[PubMed]
  • 12. Workowski KA, Bolan GA, Centers for Disease C. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015; 64: 1-137[PubMed]
  • 13. Mant C, Cason J, Rice P, Best JM. Non-sexual transmission of cervical cancer-associated papillomaviruses: an update. Papillomavirus Rep. 2000; 11(1): 1-5
  • 14. Ferenczy A. HPV-associated lesions in pregnancy and their clinical implications. Clin Obstet Gynecol. 1989; 32(1): 191-9[PubMed]
  • 15. Derkay CS, Wiatrak B. Recurrent respiratory papillomatosis: a review. Laryngoscope. 2008; 118(7): 1236-47[DOI][PubMed]
  • 16. Khan F, Mays R, Brooks J. Viral and sexually transmitted disease. Text Atlas of Obstetric Dermatology. 2013; : 126-40
  • 17. Zuo Z, Goel S, Carter JE. Association of cervical cytology and HPV DNA status during pregnancy with placental abnormalities and preterm birth. Am J Clin Pathol. 2011; 136(2): 260-5[DOI][PubMed]
  • 18. MacMahan E, Fox E, Lockwood D. Gynecologic dermatology. Obstetric and Gynecologic Dermatology. 2008; : 107-19
  • 19. Bonnez W, Elswick RK Jr, Bailey-Farchione A, Hallahan D, Bell R, Isenberg R, et al. Efficacy and safety of 0.5% podofilox solution in the treatment and suppression of anogenital warts. Am J Med. 1994; 96(5): 420-5[PubMed]
  • 20. Tyring SK, Arany I, Stanley MA, Tomai MA, Miller RL, Smith MH, et al. A randomized, controlled, molecular study of condylomata acuminata clearance during treatment with imiquimod. J Infect Dis. 1998; 178(2): 551-5[PubMed]
  • 21. Beutner KR, Spruance SL, Hougham AJ, Fox TL, Owens ML, Douglas JM Jr. Treatment of genital warts with an immune-response modifier (imiquimod). J Am Acad Dermatol. 1998; 38(2 Pt 1): 230-9[PubMed]
  • 22. Lacey CJN. Genital warts and mucosal papillomavirus disease. Medicine. 2014; 42(7): 349-53[DOI]
  • 23. Lacey CJ, Woodhall SC, Wikstrom A, Ross J. 2012 European guideline for the management of anogenital warts. J Eur Acad Dermatol Venereol. 2013; 27(3)-70[DOI][PubMed]
  • 24. Ciavattini A, Tsiroglou D, Vichi M, Di Giuseppe J, Cecchi S, Tranquilli AL. Topical Imiquimod 5% cream therapy for external anogenital warts in pregnant women: report of four cases and review of the literature. J Matern Fetal Neonatal Med. 2012; 25(7): 873-6[DOI][PubMed]
  • 25. Recurrent condylomata acuminata treated with recombinant interferon alpha-2a. A multicenter double-blind placebo-controlled clinical trial. Condylomata International Collaborative Study Group. Acta Derm Venereol. 1993; 73(3): 223-6[PubMed]
  • 26. Reid R, Greenberg MD, Pizzuti DJ, Omoto KH, Rutledge LH, Soo W. Superficial laser vulvectomy. V. Surgical debulking is enhanced by adjuvant systemic interferon. Am J Obstet Gynecol. 1992; 166(3): 815-20[PubMed]
  • 27. Petersen CS, Bjerring P, Larsen J, Blaakaer J, Hagdrup H, From E, et al. Systemic interferon alpha-2b increases the cure rate in laser treated patients with multiple persistent genital warts: a placebo-controlled study. Genitourin Med. 1991; 67(2): 99-102[PubMed]
  • 28. Fleshner PR, Freilich MI. Adjuvant interferon for anal condyloma. A prospective, randomized trial. Dis Colon Rectum. 1994; 37(12): 1255-9[PubMed]
  • 29. Armstrong DK, Maw RD, Dinsmore WW, Blaakaer J, Correa MA, Falk L, et al. Combined therapy trial with interferon alpha-2a and ablative therapy in the treatment of anogenital warts. Genitourin Med. 1996; 72(2): 103-7[PubMed]
  • 30. Douglas JJ, Eron LJ, Judson FN, Rogers M, Alder MB, Taylor E, et al. A randomized trial of combination therapy with intralesional interferon alpha 2b and podophyllin versus podophyllin alone for the therapy of anogenital warts. J Infect Dis. 1990; 162(1): 52-9[PubMed]
  • 31. Armstrong DK, Maw RD, Dinsmore WW, Morrison GD, Pattman RS, Watson PG, et al. A randomised, double-blind, parallel group study to compare subcutaneous interferon alpha-2a plus podophyllin with placebo plus podophyllin in the treatment of primary condylomata acuminata. Genitourin Med. 1994; 70(6): 389-93[PubMed]
  • 32. Handley JM, Horner T, Maw RD, Lawther H, Dinsmore WW. Subcutaneous interferon alpha 2a combined with cryotherapy vs cryotherapy alone in the treatment of primary anogenital warts: a randomised observer blind placebo controlled study. Genitourin Med. 1991; 67(4): 297-302[PubMed]
  • 33. Bleeker MC, Hogewoning CJ, Voorhorst FJ, van den Brule AJ, Snijders PJ, Starink TM, et al. Condom use promotes regression of human papillomavirus-associated penile lesions in male sexual partners of women with cervical intraepithelial neoplasia. Int J Cancer. 2003; 107(5): 804-10[DOI][PubMed]
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