Journal of Obstetrics, Gynecology and Cancer Research

Published by: Kowsar

Effects of Zinc Sulfate on Subfertility Related to Male Factors: A Prospective Double-Blind, Randomized, Placebo-Controlled Clinical Trial

Authors Information
1 Department of Obstetrics and Gynocology, Iran University of Medical Sciences, Tehran, IR Iran
2 Department of Community Medicine, Iran University of Medical Sciences, Tehran, IR Iran
Article Notes and Dates
Journal of Obstetrics, Gynecology and Cancer Research: August 31, 2016, 1 (2); e7242.Published Online: July 10, 2016
Article Type: Research Article; Received : June 20, 2016; Accepted : June 28, 2016

To Cite : Sharifzadeh F, Norouzi S, Ashrafi M, Aminimoghaddam S, Koohpayezadeh J. et al. Effects of Zinc Sulfate on Subfertility Related to Male Factors: A Prospective Double-Blind, Randomized, Placebo-Controlled Clinical Trial, J Obstet Gynecol Cancer Res. 2016 ;1(2):e7242. doi: 10.17795/ojcr-7242.

Copyright: Copyright © 2016, Journal of Obstetrics, Gynecology and Cancer Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Auger J, Kunstmann JM, Czyglik F, Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med. 1995; 332(5): 281-5[DOI][PubMed]
  • 2. Irvine S, Cawood E, Richardson D, MacDonald E, Aitken J. Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over 11 years. BMJ. 1996; 312(7029): 467-71[PubMed]
  • 3. Skakkebaek NE, Giwercman A, de Kretser D. Pathogenesis and management of male infertility. Lancet. 1994; 343(8911): 1473-9[PubMed]
  • 4. Kuroki Y, Iwamoto T, Lee J, Yoshiike M, Nozawa S, Nishida T, et al. Spermatogenic ability is different among males in different Y chromosome lineage. J Hum Genet. 1999; 44(5): 289-92[DOI][PubMed]
  • 5. van Pelt AM, de Rooij DG. Retinoic acid is able to reinitiate spermatogenesis in vitamin A-deficient rats and high replicate doses support the full development of spermatogenic cells. Endocrinology. 1991; 128(2): 697-704[DOI][PubMed]
  • 6. Ciereszko A, Dabrowski K. Sperm quality and ascorbic acid concentration in rainbow trout semen are affected by dietary vitamin C: an across-season study. Biol Reprod. 1995; 52(5): 982-8[PubMed]
  • 7. Gregory J, Foster K, Tyler H, Wiseman M. The dietary and nutritional survey of British adults. . 1990;
  • 8. de Bree A, van Dusseldorp M, Brouwer IA, van het Hof KH, Steegers-Theunissen RP. Folate intake in Europe: recommended, actual and desired intake. Eur J Clin Nutr. 1997; 51(10): 643-60[PubMed]
  • 9. Favier AE. The role of zinc in reproduction. Hormonal mechanisms. Biol Trace Elem Res. 1992; 32: 363-82[PubMed]
  • 10. Galdes A, Vallee BL. Categories of zinc metalloenzymes. 1983; 1
  • 11. Freedman LP. Anatomy of the steroid receptor zinc finger region. Endocr Rev. 1992; 13(2): 129-45[DOI][PubMed]
  • 12. Menkveld R, Wong WY, Lombard CJ, Wetzels AM, Thomas CM, Merkus HM, et al. Semen parameters, including WHO and strict criteria morphology, in a fertile and subfertile population: an effort towards standardization of in-vivo thresholds. Hum Reprod. 2001; 16(6): 1165-71[PubMed]
  • 13. Laboratory manual for the examination of human semen and semen-cervical mucus interaction. 1992;
  • 14. Menkveld R, Stander FS, Kotze TJ, Kruger TF, van Zyl JA. The evaluation of morphological characteristics of human spermatozoa according to stricter criteria. Hum Reprod. 1990; 5(5): 586-92[PubMed]
  • 15. Dony JM, Smals AG, Rolland R, Fauser BC, Thomas CM. Effect of aromatase inhibition by delta 1-testolactone on basal and luteinizing hormone-releasing hormone-stimulated pituitary and gonadal hormonal function in oligospermic men. Fertil Steril. 1985; 43(5): 787-92[PubMed]
  • 16. Hartoma TR, Nahoul K, Netter A. Zinc, plasma androgens and male sterility. Lancet. 1977; 2(8048): 1125-6[PubMed]
  • 17. Tikkiwal M, Ajmera RL, Mathur NK. Effect of zinc administration on seminal zinc and fertility of oligospermic males. Indian J Physiol Pharmacol. 1987; 31(1): 30-4[PubMed]
  • 18. Landau B, Singer R, Klein T, Segenreich E. Folic acid levels in blood and seminal plasma of normo- and oligospermic patients prior and following folic acid treatment. Experientia. 1978; 34(10): 1301-2[PubMed]
  • 19. Ghishan FK, Said HM, Wilson PC, Murrell JE, Greene HL. Intestinal transport of zinc and folic acid: a mutual inhibitory effect. Am J Clin Nutr. 1986; 43(2): 258-62[PubMed]
  • 20. Quinn PB, Cremin FM, O'Sullivan VR, Hewedi FM, Bond RJ. The influence of dietary folate supplementation on the incidence of teratogenesis in zinc-deficient rats. Br J Nutr. 1990; 64(1): 233-43[PubMed]
  • 21. Favier M, Faure P, Roussel AM, Coudray C, Blache D, Favier A. Zinc deficiency and dietary folate metabolism in pregnant rats. J Trace Elem Electrolytes Health Dis. 1993; 7(1): 19-24[PubMed]
  • 22. Wong WY, Thomas CMG, Merkus JMWM, Zielhuis GA, Steegers-Theunissen RPM. Male factor subfertility: possible causes and the impact of nutritional factors. Fertil Steril. 2000; 73: 435-42
  • 23. Chia SE, Ong CN, Chua LH, Ho LM, Tay SK. Comparison of zinc concentrations in blood and seminal plasma and the various sperm parameters between fertile and infertile men. J Androl. 2000; 21(1): 53-7[PubMed]
  • 24. Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Steegers-Theunissen RP. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2002; 77(3): 491-8[PubMed]
  • 25. Tielemans E, Heederik D, Burdorf A, Loomis D, Habbema DF. Intraindividual variability and redundancy of semen parameters. Epidemiology. 1997; 8(1): 99-103[PubMed]
  • 26. Neuwinger J, Behre HM, Nieschlag E. External quality control in the andrology laboratory: an experimental multicenter trial. Fertil Steril. 1990; 54: 308-14
  • 27. Colagar AH, Marzony ET, Chalchi MJ . The role of antioxidant therapy in the treatment of male infertility. Human Fertil. 2010; 13(4): 217-25
  • 28. Ashok A, Sekhon LH. Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified? Indian J Urolog. 2011; 27(1): 74
  • 29. Zanaty S, Malm J, Giwercman A. Visco-elasticity of seminal fluid in relation to the epididymal and accessory sex gland function and its impact on sperm motility. Int J Androl. 2004; 27(2): 94-100[DOI][PubMed]
  • 30. Zhou J, Chen L, Li J, Li H, Hong Z, Xie M, et al. The Semen pH Affects Sperm Motility and Capacitation. PLoS One. 2015; 10(7)[DOI][PubMed]
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