Gynecology Oncology
Aida Uzaya; Syahrul Rauf; Trika Irianta; Firdaus Hamid; John Rambulangi; Abdul Rahman
Articles in Press, Accepted Manuscript, Available Online from 12 February 2024
Abstract
Background and Aim: Ovarian cancer affects women worldwide. Immunoregulatory cytokines, particularly interleukin (IL)-6, can enhance tumorigenicity and are persistently secreted by ovarian cancer cells. This study aims to examine IL-6 as a marker of preoperative epithelial ovarian malignancy.
Methods: ...
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Background and Aim: Ovarian cancer affects women worldwide. Immunoregulatory cytokines, particularly interleukin (IL)-6, can enhance tumorigenicity and are persistently secreted by ovarian cancer cells. This study aims to examine IL-6 as a marker of preoperative epithelial ovarian malignancy.
Methods: This study used a cross-sectional design on 81 eligible patients with ovarian neoplasms who were undergoing surgery at the Dr. Wahidin Sudirohusodo Hospital and its networking hospital from October 2021 to June 2022. The ELISA technique was used to measure serum IL-6 from the peripheral vein. In addition, the CA-125 levels, risk of malignancy (RMI) index, and proportion of blood cells were analyzed. Chi-square analysis of the data had been used.
Results: Most of the subjects were presented as malignant ovarian neoplasms (66.7%), followed by benign ovarian neoplasms (33.3%). IL-6 level ≥ 3.75 pg/mL was found in 72.8% of patients. In individuals with epithelial ovarian neoplasms, IL-6 levels did not significantly differ between malignant and benign types (p > 0.05). CA-125 levels, RMI, ascites, and tumor size differed significantly in patients with ovarian epithelial neoplasms between malignant and benign types (p <0.05). Leukocyte levels, hemoglobin levels, platelet levels, age, parity, and age of menarche were not significantly different in epithelial ovarian neoplasm patients between malignant and benign types (p > 0.05).
Conclusion: The preoperative serum IL-6 level cannot be used as a marker of ovarian malignancy. However, this study confirms the relationship between the CA-125 level, RMI, ascites, and tumor size with the malignancy of ovarian tumors.
maliheh Arab; shahla Noori Ardabili; poria Ganji
Volume 3, Issue 1 , March and April 2018, , Pages 39-44
Abstract
Introduction Endometrial cancer is one of the most common malignancies in women globally. The laparoscopic approach from endometrial cancer is suggested in the medical literature. The aim of the present review is to clarify clinical points of laparoscopic operation in endometrial cancer. A search using ...
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Introduction Endometrial cancer is one of the most common malignancies in women globally. The laparoscopic approach from endometrial cancer is suggested in the medical literature. The aim of the present review is to clarify clinical points of laparoscopic operation in endometrial cancer. A search using keywords included endometrial carcinoma, and treatment and laparoscopy were conducted on PubMed, Up-To-Date, Ovid and Clinical Key databases up to 2016.
Conclusion This present review research showed over 1600 full-text manuscripts, of which, 18 were relevant to this article. The laparoscopic approach to endometrial cancer is categorized as follows: 1) Comparison of complications and advantages of laparoscopy and laparotomy in endometrial cancer; 2) Hospitalization days; 3) Blood transfusion and blood loss; 4) Comparison of the operation time of laparoscopy versus laparotomy; 5) Conversion of laparoscopy to laparotomy; 6) Comparison of endometrial cancer lymphadenectomy in laparoscopy with laparotomy; 7) Laparoscopy of endometrial cancer in old age; 8) Surgical experience and learning curve; 9) Technical points in laparoscopic endometrial cancer surgery; 10) Comparison of endometrial cancer survival in laparoscopy and laparotomy methods; 11) Cost issues.
Atefeh Moridi; Maliheh Arab; Ghazaleh Fazli; Maryam Khayamzadeh
Volume 1, Issue 3 , November and December 2016
Abstract
Dermoid cyst is a benign and common ovarian neoplasm affecting women. Sources for this review article were taken from PubMed and other up-to-date databases covering the period from Jan 2010 to Jan 2016. Keywords for the search were “dermoid cyst” and “treatment”. A search of the ...
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Dermoid cyst is a benign and common ovarian neoplasm affecting women. Sources for this review article were taken from PubMed and other up-to-date databases covering the period from Jan 2010 to Jan 2016. Keywords for the search were “dermoid cyst” and “treatment”. A search of the literature revealed 113 full text manuscripts, from which 21 were relevant. In addition, another 56 relevant manuscripts identified in the reference lists of the above-mentioned 21 manuscripts were included in the study, although they had been published before 2010. Clinical considerations for dermoid cyst management are categorized as follows: 1) selection of the best choice of surgical treatment in dermoid cyst: laparoscopy or laparotomy; 2) procedure to exteriorize a dermoid cyst in laparoscopy; 3) selection of oophorectomy or cystectomy; 4) spillage of the cyst contents: prevention and treatment of the consequences if it does happen; 5) necessity of surgical treatment in dermoid cyst management; 6) ovarian torsion and other complications; 7) Probability of malignancy in dermoid cyst.
