Gynecology Oncology
Akram Ghahghaei-Nezamabadi; Afsaneh Tehranian; Setareh Akhavan; Elahe Rezayof; Nooshan Tajik
Articles in Press, Accepted Manuscript, Available Online from 11 May 2024
Abstract
Background & Objective: Immunosuppression, HPV persistence, and smoking are the main related risk factors of cervical intraepithelial neoplasia (CIN) recurrence. However, age as a basic factor may be a main factor related to CIN recurrence. Therefore, our study aimed to detect the potential role ...
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Background & Objective: Immunosuppression, HPV persistence, and smoking are the main related risk factors of cervical intraepithelial neoplasia (CIN) recurrence. However, age as a basic factor may be a main factor related to CIN recurrence. Therefore, our study aimed to detect the potential role of women's age in CIN recurrence.Materials & Methods: This cross-sectional study was conducted on 329 patients who underwent conization in the gynecology-oncology clinics of Arash and Imam Khomeini hospitals affiliated with Tehran University of Medical Sciences between February 2016 and February 2021.Results: Totally, 329 cases were enrolled in the study. Most women were in their thirties. CIN recurrence was about 10.0% (32 cases). The CIN recurrence rate was 8.9% in women younger than 30, 10.2% in 30-40, 11.3% in 40-50, and 5.6% in 50-60 decades. There was no significant (p-value=0.802) difference in recurrence rate among age groups. There was a significant (p-value=0.023) difference in the frequency of endocervical involvement regarding age category, women aged 40 to 50 had the most frequent marginal involvement with 26.8%, while there was no significant (p-value=0.802) difference in frequency of marginal involvement regards age category.Conclusion: CIN cases with age higher than 40 years need to have more caution and tight follow-up visit after conization.
Maternal Fetal Medicine
Yusra Shakir Abdulzahra; Sanaa Jameel Thamer
Articles in Press, Accepted Manuscript, Available Online from 13 May 2024
Abstract
Background: Neuregulin 4(Nrg4) was found to be highly enriched in brown adipose tissue and plays an important role in regulating glucolipid metabolism. Concentrations of Nrg4 and their relationship with insulin, as well as inflammatory markers IL8 and TNFα, were investigated in individuals with ...
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Background: Neuregulin 4(Nrg4) was found to be highly enriched in brown adipose tissue and plays an important role in regulating glucolipid metabolism. Concentrations of Nrg4 and their relationship with insulin, as well as inflammatory markers IL8 and TNFα, were investigated in individuals with metabolic disorders such as obesity and Type 2 Diabetes (T2D), in the context of insulin resistance in women.
Methods: Within a cross-sectional study, a total of 73 female participants aged 30 to 60 years categorized into three groups: (1) healthy obese (n=21), (2) Newly diagnosed T2D (n=21), and (3) treated T2D (n=31). Various body anthropometric measurements were assessed, and blood tests were conducted to analyze serum glucose levels, lipid profiles, insulin levels, and adipokines.
Results: It was found that levels of Nrg4 in healthy obese and newly diagnosed T2D were increased compared with treated T2D with (p= 0.007), and (p= 0.005) respectively. In treated T2D group there was a positive correlation detected between serum Nrg4 and each of insulin (r= 0.699, p ˂0.001), HOMA-IR (r= 0.725, p ˂0.001), and IL8 (r= 0.395, p= 0.028), and in healthy obese group with HbA1c and IL8 (r= 0.492, p= 0.023; r=0.579, p= 0.006) respectively. In a total of participants, Nrg4 correlated positively with TNFα (r= 0.580, p ˂0.001).
Conclusion: Nrg4 levels increase in obesity and newly diagnosed diabetes, correlating with hyperglycemia, insulin resistance, and inflammation.
