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Volume 4, Issue 4 (Fall 2019)                   J Obstet Gynecol Cancer Res 2019, 4(4): 135-140 | Back to browse issues page

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Karimian F, Akhavan S, Marzoughi A, Keramati M R, Ashouri M. Correlation between correction of Menstrual Irregularity and Diminution of Cyclic Mastalgia. J Obstet Gynecol Cancer Res. 2019; 4 (4) :135-140
URL: http://jogcr.com/article-1-261-en.html
1- Department of Surgery, Tehran University of Medical Sciences, Imam Khomeini Teaching Hospital, Tehran, Iran , faramarz.karimian@gmail.com
2- Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Imam Khomeini Teaching Hospital, Tehran, Iran
3- Former Resident Tehran University of Medical Science, Department of Surgery, Imam Khomeini Teaching Hospital, Tehran, Iran
4- Department of Surgery, Tehran University of Medical Sciences, Imam Khomeini Teaching Hospital, Tehran, Iran
Abstract:   (1899 Views)

Background & Objective: Cyclic mastalgia is clinically related to alterations in sex hormone levels during the menstrual cycle. A derangement in normal menstrual cycle leads to exacerbated mastalgia; which can also cause menstrual irregularities and abnormal uterine bleeding (AUB). A decrease in severity of mastalgia is observed in patients with simultaneous cyclic mastalgia and menstrual irregularities/AUB, following correction of menstrual irregularity. This study was designed and conducted to investigate the possibility of whether correction of menstrual irregularities can diminish cyclic mastalgia.
Materials & Methods: This case-control study was carried out on women suffering from simultaneous mastalgia and menstrual irregularity. One-hundred and fifty patients were randomly distributed between case and control groups, each including 75 patients. Patients in both groups took 100 mg vitamin E oral tablet daily for 3 months. Patients in case group also received low-dose oral contraceptive pills (OCP-LD) to correct menstrual irregularity. Patients recorded the severity of mastalgia in Cardiff breast pain chart using Visual Analogue Scale (VAS).
Results: At the beginning of study, there was no significant difference in the number of days suffering from mild and severe mastalgia between two groups. However, at the end of the study, mild and severe mastalgia reduced significantly in the case group compared to the control group (P=0.003 and P=0.045, respectively).
Conclusion: In women with cyclic mastalgia, correction of menstrual irregularity leads to significant pain relief. Correcting menstrual irregularity is suggested as a first-line treatment in women with mastalgia.

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Systematic Review: Original Research | Subject: General surgery
Received: 2020/04/15 | Accepted: 2020/05/19 | Published: 2020/05/19

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