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Volume 5, Issue 3 (Summer 2020)                   J Obstet Gynecol Cancer Res 2020, 5(3): 115-125 | Back to browse issues page

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Bakhtiari M, Babaei T, Safarpour M, Esmaeili M, Esmaeili M, Asgari R et al . Investigating the Factors Affecting the ICSI (microinjection) Success in Infertile People Referred to an Infertility Treatment Center in Western Iran from 2011 to 2017. J Obstet Gynecol Cancer Res 2020; 5 (3) :115-125
URL: http://jogcr.com/article-1-290-en.html
1- Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Student Research Committee, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Medical Biology Research Center, Health Technology institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
4- Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran , roshankhah@yahoo.com
Abstract:   (1873 Views)

Background & objective: Various parameters can affect the success of intra cytoplasmic sperm injection (ICSI). This study aims to compare the results of fertility in formerly infertile couples who underwent ICSI considering different parameters.
Materials & Methods: In this retrospective study, 261 cases of infertile couples who referred to Motazedi Infertility Center in Kermanshah, and had successful ICSI from 2011 to 2017, were examined. Statistical analysis was performed after collecting the data.
Results: The highest ICSI success rates were in the age range of 31-40 years (58.2%), and 21-30 years (55.8%), in men and women, respectively. Regarding the duration of infertility, the highest success rate was observed in couples who were infertile for less than five years (51.8%). In this study, all the patients’ endometrial thicknesses were normally higher than 4 mm. In terms of the number of embryos formed, the success percentage was 68% with three formed embryos. The hormonal variations and distribution percentages were as following: AMH ranging from 1.01 to 5 ng/mL (55.6%), TES ranging from 0 to 50 nmol/L (53%), TSH ranging from 1.01 to 5 μU/mL (81.6%), FSH ranging from 5.01 to 10 IU/L (58.9%), PRO ranging from 5.01 to 10 ng/mL (24%), LH ranging from 1.01 to 5 IU/L (46.7%), and DHEA-S ranging from 1.01 to 5 ng/mL (18.9%).
Conclusion: According to the results, it seems that the success of ICSI technique in infertile couples depends on some parameters including variations in reproductive hormones, number of embryos, couples’ ages, and duration of infertility.

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Systematic Review: Original Research | Subject: Reproductive Medicine
Received: 2020/06/1 | Accepted: 2020/08/3 | Published: 2020/11/30

1. Mu Q, Hanson L, Hoelzle J, Fehring RJ. Young Women's Knowledge About Fertility and Their Fertility Health Risk Factors. J Obstet Gynecol Neonatal Nurs. 2019;48(2):153-62. [DOI:10.1016/j.jogn.2018.12.009] [PMID]
2. Check J, Yuan W, Garberi-Levito M, Swenson K, McMonagle K. Effect of method of oocyte fertilization on fertilization, pregnancy and implantation rates in women with unexplained infertility. Clin Exp Obstet Gynecol. 2011;38(3):203-5.
3. Palermo G, Joris H, Devroey P, Van Steirteghem AC. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet. 1992;340(8810):17-8. [DOI:10.1016/0140-6736(92)92425-F]
4. Dyer S, Chambers GM, de Mouzon J, Nygren K-G, Zegers-Hochschild F, Mansour R, et al. International Committee for Monitoring AssistedReproductive Technologies world report: assisted reproductive technology 2008, 2009 and 2010. Hum reprod. 2016;31(7):1588-609. [DOI:10.1093/humrep/dew082] [PMID]
5. Boulet SL, Mehta A, Kissin DM, Warner L, Kawwass JF, Jamieson DJ. Trends in use of and reproductive outcomes associated with intracytoplasmic sperm injection. Jama. 2015;313(3):255-63. [DOI:10.1001/jama.2014.17985] [PMID] [PMCID]
6. Blake M, Garrisi J, Tomkin G, Cohen J. Sperm deposition site during ICSI affects fertilization and development. Fertil Steril. 2000;73(1):31-7. [DOI:10.1016/S0015-0282(99)00465-3]
7. Lie RT, Lyngstadass A, Ørstavik KH, Bakketeig LS, Jacobsen G, Tanbo T. Birth defects in children conceived by ICSI compared with children conceived by other IVF-methods; a meta-analysis. Int J Epidemiol. 2005;34(3):696-701. [DOI:10.1093/ije/dyh363] [PMID]
8. Wen J, Jiang J, Ding C, Dai J, Liu Y, Xia Y, Liu J, Hu Z. Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis. Fertil steril. 2012 Jun 1;97(6):1331-7. [DOI:10.1016/j.fertnstert.2012.02.053] [PMID]
9. Kim JY, Kim JH, Jee BC, Lee JR, Suh CS, Kim SH. Can intracytoplasmicsperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility? Eur J Obstet Gynecol Reprod Biol. 2014;178:188-91. [DOI:10.1016/j.ejogrb.2014.03.044] [PMID]
10. Tannus S, Son W-Y, Gilman A, Younes G, Shavit T, Dahan M-H. The role of intracytoplasmic sperm injection in non-male factor infertility in advanced maternal age. Hum Reprod. 2017;32(1):119-24. [DOI:10.1093/humrep/dew298] [PMID]
11. Park JH, Jee BC, Kim SH. Comparison of normal and abnormal fertilization of in vitro‐matured human oocyte according to insemination method. J Obstet Gynaecol Res. 2016;42(4):417-21. [DOI:10.1111/jog.12916] [PMID]
12. Pisarska MD, Casson PR, Cisneros PL, Lamb DJ, Lipshultz LI, Buster JE, Carson SA. Fertilization after standard in vitro fertilization versus intracytoplasmic sperm injection in subfertile males using sibling oocytes. Fertil steril. 1999;71(4):627-32. [DOI:10.1016/S0015-0282(98)00538-X]
13. Elizur SE, Levron J, Seidman DS, Kees S, Levran D, Dor J. Conventional in vitro fertilization versus intracytoplasmic sperm injection for sibling oocytes in couples with mild oligoteratoasthenozoospermia and couples with normal sperm. Fertil Steril. 2004;82(1):241-3. [DOI:10.1016/j.fertnstert.2003.11.053] [PMID]
14. Hershlag A, Paine T, Kvapil G, Feng H, Napolitano B. In vitro fertilization-intracytoplasmic sperminjection split: an insemination method to prevent fertilization failure. Fertil Steril. 2002;77(2):229-32. [DOI:10.1016/S0015-0282(01)02978-8]
15. Bhattacharya S, Hamilton MP, Shaaban M, Khalaf Y, Seddler M, Ghobara T, Braude P, Kennedy R, Rutherford A, Hartshorne G, Templeton A. Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial. Lancet. 2001;357(9274):2075-9. [DOI:10.1016/S0140-6736(00)05179-5]
16. Practice Committies of the American Society for Reproductive Medicine and Society for Assisted Reproductive Technology. Intracytoplasmic sperm injection (ICSI) for non-male factor infertility: a committee opinion.Fertil Steril. 2012;98(6):1395-9. [DOI:10.1016/j.fertnstert.2012.08.026] [PMID]
17. Pagidas K, Falcone T, Hemmings R, Miron P. Comparison of reoperation for moderate (stage III) and severe (stage IV) endometriosis-related infertility with in vitro fertilization-embryo transfer. Fertil Steril. 1996;65(4):791-5. [DOI:10.1016/S0015-0282(16)58215-6]
18. Bleil ME, Gregorich SE, Adler NE, Sternfeld B, Rosen MP, Cedars MI. Race/ethnic disparities in reproductive age: an examination of ovarian reserve estimates across four race/ethnic groups of healthy, regularly cycling women. Fertil Steril. 2014;101(1):199-207. [DOI:10.1016/j.fertnstert.2013.09.015] [PMID] [PMCID]
19. Shaw ND, Srouji SS, Welt CK, Cox KH, Fox JH, Adams JM, Sluss PM, Hall JE. Evidence that increased ovarian aromatase activity and expression account for higher estradiol levels in African American compared with Caucasian women. J Clin Endocrinol Metab. 2014;99(4):1384-92. [DOI:10.1210/jc.2013-2398] [PMID] [PMCID]
20. Tal R, Seifer DB. Potential mechanisms for racial and ethnic differences in antimüllerian hormone and ovarian reserve. Int J endocrinol. 2013;2013. [DOI:10.1155/2013/818912] [PMID] [PMCID]
21. Du X, Ding T, Zhang H, Zhang C, Ma W, Zhong Y, Qu W, Zheng J, Liu Y, Li Z, Huang K. Age-specific normal reference range for serum anti-müllerian hormone in healthy Chinese Han women: a nationwide population-based study. Reprod Sci. 2016;23(8):1019-27. [DOI:10.1177/1933719115625843] [PMID]
22. Yoo JH, Kim HO, Cha SW, Park CW, Yang KM, Song IO, Koong MK, Kang IS. Age specific serum anti-Müllerian hormone levels in 1,298 Korean women with regular menstruation. Clin Exp Reprod Med. 2011;38(2):93. [DOI:10.5653/cerm.2011.38.2.93] [PMID] [PMCID]
23. Gupta S, Karuputhula N, Kumar N, SrivastavaA, Singh B, Dubey K. Correlation of basal serum anti-Mullerian hormone level with oocyte quality and embryo development potential in women undergoing IVF-ICSI. Fertil Sci Res. 2017;4(2):112. [DOI:10.4103/fsr.fsr_8_18]
24. Barbakadze L, Kristesashvili J, Khonelidze N, Tsagareishvili G. The correlations of anti-mullerian hormone, follicle-stimulating hormone and antral follicle count in different age groups of infertile women. Int J Fertil Steril. 2015;8(4):393.
25. Te Velde ER, Pearson PL. The variability of female reproductive ageing. Hum Reprod Update. 2002;8(2):141-54. [DOI:10.1093/humupd/8.2.141] [PMID]
26. Yang D, Haines CJ, Pan P, Zhang Q, Sun Y, Hong S, Tian F, Bai B, Peng X, Chen W, Yang X. Menopausal symptoms in mid-life women in southern China. Climacteric. 2008;11(4):329-36. [DOI:10.1080/13697130802239075] [PMID]
27. Hamdine O, Eijkemans MJ, Lentjes EW, Torrance HL, Macklon NS, Fauser BC, Broekmans FJ. Ovarian response prediction in GnRH antagonist treatment for IVF using anti-Müllerian hormone. Hum Reprod. 2015;30(1):170-8. [DOI:10.1093/humrep/deu266] [PMID]
28. Souza M, Mancebo A, Silva J, Antunes R, Souza M. Prediction of metaphase II oocytes according to diferent serum anti-Müllerian hormone (AMH) in antagonist ICSI cycles. JBRA Assist Reprod. 2014;18:98-125.
29. Smulders B, van Oirschot SM, Farquhar C, Rombauts L, Kremer JA. Oral contraceptive pill, progestogenor estrogen pre‐treatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques. Cochrane Database Syst Rev. 2010; (1). [DOI:10.1002/14651858.CD006109.pub2]
30. Bjercke S, Fedorcsak P, Åbyholm T, Storeng R, Ertzeid G, Oldereid N, Omland A, Tanbo T. IVF/ICSI outcome and serum LH concentration on day 1 of ovarian stimulation with recombinant FSH under pituitary suppression. Hum Reprod. 2005;20(9):2441-7. [DOI:10.1093/humrep/dei101] [PMID]
31. Kolibianakis EM, Venetis CA, Bosdou JK, Zepiridis L, Chatzimeletiou K, Makedos A, Masouridou S, Triantafillidis S, Mitsoli A, Tarlatzis BC. Corifollitropin alfa compared with follitropin beta in poor responders undergoing ICSI: a randomized controlled trial. Hum Reprod. 2015;30(2):432-40. [DOI:10.1093/humrep/deu301] [PMID]
32. Tannus S, Turki R, Cohen Y, Son W-Y, Shavit T, Dahan MH. Reproductive outcomes after a single dose ofgonadotropin-releasing hormone agonist compared with human chorionic gonadotropin for the induction of final oocyte maturation in hyper-responder women aged 35-40 years. Fertil Steril. 2017;107(6):1323-8. e2. [DOI:10.1016/j.fertnstert.2017.04.014] [PMID]
33. Andersen AN, Witjes H, Gordon K, Mannaerts B. Predictive factors of ovarian response and clinical outcome after IVF/ICSI following a rFSH/GnRH antagonist protocol with or without oral contraceptive pre-treatment. Hum Reprod. 2011;26(12):3413-23. [DOI:10.1093/humrep/der318] [PMID]
34. Evliyaoglu O, Imöhl M, Weiskirchen R, van Helden J. Age-specific reference values improve the diagnostic performance of AMH in polycystic ovary syndrome. Clin Chem Lab Med. 2020;1. [DOI:10.1515/cclm-2019-1059] [PMID]
35. Abbassi-Ghanavati M, Greer LG, Cunningham FG. Pregnancy and laboratory studies: a reference table for clinicians. Obstet Gynecol. 2009;114(6):1326-31. [DOI:10.1097/AOG.0b013e3181c2bde8] [PMID]
36. Pavord S, Hunt B. The obstetric hematology manual: Cambridge University Press; 2018. [DOI:10.1017/9781316410837]
37. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21(10):1081-125. [DOI:10.1089/thy.2011.0087] [PMID] [PMCID]
38. Kratz A, Ferraro M, Sluss PM, Lewandrowski KB. Normal reference laboratory values. N Engl J Med. 2004;351(15):1548-63. [DOI:10.1056/NEJMcpc049016] [PMID]
39. Liao X, Jiang W, Chen X, Qiu S, Sun Y, Zhu S. Modified super-long downregulation protocol improves clinical outcomes of IVF/ICSI-ET in infertile patients with endometriosis. Int J Clin Exp Med. 2018;11(9):9958-65.
40. Çiray HN, Ulug U, Tosun S, Erden HF, Bahceci M. Outcome of 1114 ICSI and embryo transfer cycles of women 40 years of age and over. Reprod Biomed Online. 2006;13(4):516-22. [DOI:10.1016/S1472-6483(10)60639-6]

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