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Volume 6, Issue 1 (Winter 2021)                   J Obstet Gynecol Cancer Res 2021, 6(1): 22-28 | Back to browse issues page

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Taghavipour M, Galini-Moghaddam T, Mousavi S J. First and Second-Trimester Maternal Serum Analytes for the Prediction of Adverse Pregnancy Outcomes. J Obstet Gynecol Cancer Res. 2021; 6 (1) :22-28
URL: http://jogcr.com/article-1-325-en.html
1- MD, Obstetrics and Gynecology Specialist, Department of Obstetrics and Gynecology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2- MD, Obstetrics and Gynecology Specialist, Department of Obstetrics and Gynecology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran , tgmoghaddam@gmail.com
3- MD, Community Medicine Specialist, Department of Community Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Abstract:   (429 Views)
Background and Objectives: Maternal serum levels of the first- and second-trimester markers for aneuploidy have been revealed to be associated with adverse pregnancy outcomes in the absence of neural tube defects or aneuploidy. This finding can guide clinicans for early diagnosis and management of such outcomes. However, previous finding are conflicting in this regard. Therefore, this study evaluated the detection of adverse pregnancy outcomes by first- and second-trimester serum screening analytes.
Methods & Materials: We prospectively recruited 972 females who underwent first and second-trimester aneuploidy screening. We gathered information on maternal demographic characteristics and serum biomarkers (free B-hCG and PAPP-A for the first-trimester; AFP, Β-hCG, Inhibin-A, and unconjugated estradiol for second-trimester). At the end of the study, adverse pregnancy outcome was recorded.
Results: Abnormal screening results were reported in 34 (3.5%) patients. Two groups were significantly different in maternal age, BMI, and gestational period (P=0.017, 0.003 and 0.021, respectively). Among the measured adverse outcomes, preeclampsia was significantly more prevalent in the case group (P<0.0001). Abnormal levels of Inhibin-A is associated with the incidence of preeclampsia (RR: 29.87, CI: 13.22-67.49, P<0.0001). Additionally, patients with an abnormal level of Inhibin-A had a shorter gestational period (255.5 ± 24.53 vs. 264.79 ± 8.99, P=0.006). Likewise, patients with an abnormal level of maternal serum alpha-fetoprotein (MSAFP) had a shorter gestational period (252.0 ± 29.3 vs. 264.8 ± 8.93, P=0.001).
Conclusion: First- and second-trimester maternal serum biomarkers could provide a possible screening tool for early detection of preeclampsia.
Full-Text [PDF 334 kb]   (268 Downloads) |   |   Full-Text (HTML)  (140 Views)  
Systematic Review: Original Research | Subject: Maternal Fetal Medicine
Received: 2020/10/16 | Accepted: 2020/12/20 | Published: 2021/01/10

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