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Volume 6, Issue 3 (Summer 2021)                   J Obstet Gynecol Cancer Res 2021, 6(3): 116-121 | Back to browse issues page


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MohammadBeigi R, Fathollahpour A, Fathollahpour A, Kashanian M, Sheikhansari N. A Comparison Between Maternal and Neonatal Serum Level of Vitamin D and Its Relationship with Anthropometric Neonatal Factors. J Obstet Gynecol Cancer Res. 2021; 6 (3) :116-121
URL: http://jogcr.com/article-1-341-en.html
1- Department of Obstetrics and Gynecology, Akbarabadi Teaching Hospital, Iran University of Medical Sciences, Tehran, Iran
2- Department of Pediatrics, Pediatric Endocrinology and Metabolism, School of Medicine, Cancer and Immunology Research Center, Besat Hospital, Sanandaj, Iran
3- Department of Obstetrics and Gynecology, Akbarabadi Teaching Hospital, Iran University of Medical Sciences, Tehran, Iran , maryamkashanian@yahoo.com
4- School of Medicine, University of Exeter, Exeter, UK
Abstract:   (356 Views)

Background & Objective: The aims of present study were to compare the vitamin D concentration in pregnant women and the umbilical cord blood while investigating for a relationship between its level and anthropometric neonatal factors (i.e. birth weight, birth length, and head circumference).
Materials & Methods: The study was performed as a descriptive cross-sectional study on pregnant women who were admitted to the labor ward for delivery. Serum level of 25-hydroxyvitamin D [25(OH) D], was measured and compared in women and the umbilical cord blood. The relationship between 25(OH) D levels and anthropometric neonatal factors including birth weight, birth length and head circumference was evaluated.
Results: A total of 106 pregnant women (53 Iranians and 53 Afghan refugees’ women) were evaluated. There was a significant correlation between maternal serum level of 25(OH) D and that of their neonates, both in Iranians and Afghans considering gestational age as a confounding factor (R=0.62, P=0.000). Maternal and neonatal 25(OH) D levels were significantly higher in Iranians than Afghans (27.2±11.5 ng/mL VS 21.9±12.7 ng/mL, P=0.026 and 26.5±11.2 VS 17.3±11.4, P=0.000) respectively. However, neonatal weight and head circumference (HC), were not different in Iranians and Afghans except for neonatal height which was higher in Afghans (P=0.015) irrespective of lower amount of neonatal 25(OH) D levels.
The mean cord levels of vitamin D in boys and girls did not show a significant difference. There was no significant correlation between 25(OH) D serum level and pregnant women’s level of education, pre-labor rupture of membranes (PROM), past medical history (PMH), taking supplements and smoking.
Conclusion: Maternal and neonatal 25(OH) D levels did not influence neonatal anthropometry.

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Systematic Review: Original Research | Subject: Maternal Fetal Medicine
Received: 2021/02/9 | Accepted: 2021/03/25 | Published: 2021/06/18

References
1. Hayden KE, Sandle LN, Berry JL. Ethnicity and social deprivation contribute to vitamin D deficiency in an urban UK population. J Steroid Biochem Mol Biol. 2015 Apr; 148:253-5. [DOI:10.1016/j.jsbmb.2014.11.014] [PMID]
2. Moon RJ, Harvey NC, Cooper C, D'Angelo S, Curtis EM, Crozier SR, et al. Maternal Vitamin D Osteoporosis Study Trial Group. Response to Antenatal Cholecalciferol Supplementation Is Associated With Common Vitamin D-Related Genetic Variants. J Clin Endocrinol Metab. 2017 Aug 1; 102(8):2941-9. [DOI:10.1210/jc.2017-00682] [PMID] [PMCID]
3. Gordon CM, Feldman HA, Sinclair L, Williams AL, Kleinman PK, Perez-Rossello J, Cox JE. Prevalence of vitamin D deficiency among healthy infants and toddlers. Arch Pediatr Adolesc Med, 2008. 162(6): 505-12. [DOI:10.1001/archpedi.162.6.505] [PMID] [PMCID]
4. Mansbach JM, Ginde AA, Camargo CA Jr. Serum 25-hydroxyvitamin D levels among US children aged 1 to 11 years: do children need more vitamin D? Pediatrics, 2009. 124(5): 1404-10. [DOI:10.1542/peds.2008-2041] [PMID] [PMCID]
5. Saintonge S, Bang H, Gerber LM. Implications of a new definition of vitamin D deficiency in a multiracial us adolescent population: the National Health and Nutrition Examination Survey III. Pediatrics, 2009. 123(3): 797-803. [DOI:10.1542/peds.2008-1195] [PMID]
6. Ganji V, Martineau B, Van Fleit WE. Association of serum vitamin D concentrations with dietary patterns in children and adolescents. Nutr J. 2018 Jun 4; 17(1):58. [DOI:10.1186/s12937-018-0365-7] [PMID] [PMCID]
7. Care AD. Fetal calcium homeostasis. Equine Vet J Suppl. 1997 Jun ;( 24):59-61. [DOI:10.1111/j.2042-3306.1997.tb05079.x]
8. Kovacs CS. Calcium and Phosphate Metabolism and Related Disorders during Pregnancy and Lactation. 2018; https://www.ncbi.nlm.nih.gov/books/NBK279173
9. Fuleihan Gel-H, Bouillon R, Clarke B, Chakhtoura M, Cooper C, McClung M, Singh RJ. Serum 25-Hydroxyvitamin D Levels: Variability, Knowledge Gaps, and the Concept of a Desirable Range. J Bone Miner Res. 2015; 30(7):1119-33. [DOI:10.1002/jbmr.2536] [PMID]
10. Roth DE, Morris SK, Zlotkin S, Gernand AD, Ahmed T, Shanta SS, et al. Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth. N Engl J Med. 2018 Aug 9; 379(6):535-46. [DOI:10.1056/NEJMoa1800927] [PMID] [PMCID]
11. Salek M, Hashemipour M, Aminorroaya A, Gheiratmand A, Kelishadi R, Ardestani PM, et al. Vitamin D deficiency among pregnant women and their newborns in Isfahan, Iran. Exp Clin Endocrinol Diabetes. 2008 Jun; 116(6):352-6. [DOI:10.1055/s-2008-1042403] [PMID]
12. Jacquemyn Y, Ajaji M, Karepouan N. Vitamin D levels in maternal serum and umbilical cord blood in a multi-ethnic population in Antwerp, Belgium. Facts Views Vis Ob Gyn, 2013. 5(1): 3-5.
13. Bowyer L, Catling-Paull C, Diamond T, Homer C, Davis G, Craig ME. Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clin Endocrinol (Oxf), 2009. 70(3): 372-7. [DOI:10.1111/j.1365-2265.2008.03316.x] [PMID]
14. Alp H, Tekgündüz KŞ, Akkar MK. Maternal and cord blood vitamin D status in high-altitude pregnancy. J Matern Fetal Neonatal Med. 2016; 29(4):571-5. [DOI:10.3109/14767058.2015.1011119] [PMID]
15. Eichholzer M, Platz EA, Bienstock JL, Monsegue D, Akereyeni F, Hollis BW, et al. Racial variation in vitamin D cord blood concentration in white and black male neonates. Cancer Causes Control, 2013. 24(1): 91-8. [DOI:10.1007/s10552-012-0093-9] [PMID] [PMCID]
16. Bodnar LM, Simhan HN, Powers RW, Frank MP, Cooperstein E, Roberts JM. High Prevalence of Vitamin D Insufficiency in Black and White Pregnant Women Residing in the Northern United States and Their Neonates. J. Nutr. February 2007; 137(2): 447-52. [DOI:10.1093/jn/137.2.447] [PMID] [PMCID]
17. Við Streym S, Kristine Moller U, Rejnmark L, Heickendorff L, Mosekilde L, Vestergaard P. Maternal and infant vitamin D status during the first 9 months of infant life-a cohort study. Eur J Clin Nutr, 2013. 67(10): 1022-8. [DOI:10.1038/ejcn.2013.152] [PMID]
18. Sarma D, Saikia UK, Das DV. Fetal Skeletal Size and Growth are Relevant Biometric Markers in Vitamin D Deficient Mothers: A North East India Prospective Cohort Study. Indian J Endocrinol Metab. 2018 Mar-Apr; 22(2):212-6. [DOI:10.4103/ijem.IJEM_652_17] [PMID] [PMCID]
19. Wierzejska R, Jarosz M, Klemińska-Nowak M, Tomaszewska M2, Sawicki W, Bachanek M, Siuba-Strzelińska M. Maternal and Cord Blood Vitamin D Status and Anthropometric Measurements in Term Newborns at Birth. Front Endocrinol (Lausanne). 2018 Jan 25; 9:9. [DOI:10.3389/fendo.2018.00009] [PMID] [PMCID]
20. Saraf R, Morton SM, Camargo CA Jr, Grant CC. Global summary of maternal and newborn vitamin D status - a systematic review. Matern Child Nutr. 2016 Oct; 12(4):647-68. [DOI:10.1111/mcn.12210] [PMID] [PMCID]
21. Harvey NC, Holroyd C, Ntani G, Javaid K, Cooper P, Moon R, et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess. 2014 Jul; 18(45):1-190. [DOI:10.3310/hta18450] [PMCID]
22. De-Regil LM, Palacios C, Lombardo LK, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2016 Jan 14; (1):CD008873. [DOI:10.1002/14651858.CD008873.pub3] [PMID]
23. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomized trials. BMJ. 2017 Nov 29; 359:j5237. [DOI:10.1136/bmj.j5237] [PMID] [PMCID]

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