Write your message
Articles In Press : Volume 06 - Issue 04 (Fall 07-2021 - Serial : 23)                   Back to the articles list | Back to browse issues page

XML Print


1- Department of Obstetrics and Gynecology, Faculty of , University of , , Iran
2- Department of Obstetrics and Gynecology, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran , lmousavi.lm@gmail.com
Abstract:   (41 Views)

Background & Objective: Since the first reported respiratory distress syndrome due to the new version of the coronaviruses family, COVID-19, there is a concern about the possible maternal and perinatal outcome of new infection in a short and even long time, our information about the prognosis of pregnancy in sync with COVID-19 is limited. What is our task as scientists in eliminating the unknown facts?
Materials & Methods: Here we try to present a couple of pregnant cases in their third trimesters of pregnancy that complicated with two contrary complication of COVID-19 infection, intending to illuminate the best management strategy in COVID-19 infected pregnant.
Results: The first case had experienced thromboembolism, and also bleeding accident, who fortunately survived unlike the other case, who expired due to multi-organ failure and impossibility of anticoagulant agent administration for the suspected pulmonary thromboembolic accident.
Conclusion: The prior report revealed the thrombo-inflammatory and hypoxic effect of COVID-19 that could lead to microvascular thrombosis and progression, which enforce health care providers, introducing the anticoagulant agents to decline COVID-19 mortality, especially in a critically ill patient. Pregnancy is associated with coagulation abnormality which could intensify the COVID-19-induced coagulopathy. But, one should balance the harm and benefit of such a hazard approach, is there any concern about vascular damage of COVID-19 and subsequent bleeding, that could be exacerbated with high dose anticoagulant agent administration? The other question that we want to discuss in the present report is about comparing the cost and benefit of anticoagulant therapy?

     
Systematic Review: Case Report | Subject: Maternal Fetal Medicine
Received: 2021/03/9 | Accepted: 2021/05/20

References
1. Kollias A, Kyriakoulis KG, Dimakakos E, Poulakou G, Stergiou GS, Syrigos K. Thromboembolic risk and anticoagulant therapy in COVID‐19 patients: emerging evidence and call for action. Br J Haematol. 2020; 189(5):846-7. [DOI:10.1111/bjh.16727] [PMID] [PMCID]
2. Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020; [DOI:10.1111/jth.14830] [PMID] [PMCID]
3. Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID‐19. J Thromb Haemost. 2020; 18(5):1023-6. [DOI:10.1111/jth.14810] [PMID]
4. Lee SG, Fralick M, Sholzberg M. Coagulopathy associated with COVID-19. CMAJ. 2020; 192(21):E583. [DOI:10.1503/cmaj.200685] [PMID] [PMCID]
5. Connors JM, Levy JH. Thromboinflammation and the hypercoagulability of COVID‐19. J Thromb Haemost. 2020; 18(7):1559-61. [DOI:10.1111/jth.14849] [PMID]
6. Greenstein YY. Inaccurate conclusions by Tang and colleagues. J Thromb Haemost. 2020; 18(7):1797. [DOI:10.1111/jth.14857] [PMID] [PMCID]
7. Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020; 18(4):844-7. [DOI:10.1111/jth.14768] [PMID] [PMCID]
8. Kollias A, Kyriakoulis KG, Dimakakos E, Poulakou G, Stergiou GS, Syrigos K. Thromboembolic risk and anticoagulant therapy in COVID‐19 patients: emerging evidence and call for action. Br J Haematol. 2020; 189(5):846-7. [DOI:10.1111/bjh.16727] [PMID] [PMCID]
9. Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z, Zhang Z. D‐dimer levels on admission to predict in‐hospital mortality in patients with Covid‐19. J Thromb Haemost. 2020; 18(6):1324-9. [DOI:10.1111/jth.14859] [PMID] [PMCID]
10. Sahin AR, Erdogan A, Agaoglu PM, Dineri Y, Cakirci AY, Senel ME, et al. 2019 novel coronavirus (COVID-19) outbreak: a review of the current literature. Eurasian J Med Oncol. 2020; 4(1):1-7. [DOI:10.14744/ejmo.2020.12220]
11. Sharifi-Razavi A, Karimi N, Rouhani N. COVID-19 and intracerebral haemorrhage: causative or coincidental?. New Microbes New Infect. 2020; 35. [DOI:10.1016/j.nmni.2020.100669] [PMID] [PMCID]
12. Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID‐19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020; 99(7):823-9. [DOI:10.1111/aogs.13867] [PMID] [PMCID]
13. Liang H, Acharya G. Novel corona virus disease (COVID‐19) in pregnancy: What clinical recommendations to follow?. Acta Obstet Gynecol Scand. 2020; 99(4):439-42. [DOI:10.1111/aogs.13836] [PMID]
14. Naderpour Z, Saeedi M. A Primer on COVID-19 for Clinicians: Clinical Manifestation and Natural Course. Adv Emerg Nurs J. 2020; 4(2s):e62.

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2021 CC BY-NC 4.0 | Journal of Obstetrics, Gynecology and Cancer Research (JOGCR)

Designed & Developed by : Yektaweb | Piblisher: Farname Inc.