Write your message
Volume 7, Issue 3 (May & June - Volume 07 - Issue 03 2022)                   J Obstet Gynecol Cancer Res 2022, 7(3): 221-225 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Baisil S, Kundapur R, Chandramoha S, Nelliyanil M, Abhraham P, Shetty V et al . Survival Pattern Depending on Hormone Receptor Status, Stages of Breast Cancer and Social-Economic Status- A Cohort Study. J Obstet Gynecol Cancer Res. 2022; 7 (3) :221-225
URL: http://jogcr.com/article-1-486-en.html
1- Department of Community Medicine, MOSC Medical College, Kolenchery, Cochin, India
2- All India Institute of Medical Sciences, Bibinagar, Hyderabad, India
3- Department of Community Medicine, Government Medical College, Konni Pathanamthitta, India
4- Department of Community Medicine A. J. Institute of Medical Sciences and Research Center Mangaluru, Karnataka, India , drmarian@ajims.edu.in
5- Department of Community Medicine, Mount Zion Medical College, Adoor, India
6- Department of Oncology, K. S. Hegde Medical Academy, Mangalore, India
7- Department of Surgery, K. S. Hegde Medical Academy, Mangalore, India
Abstract:   (163 Views)

Background and Objective: Breast cancer is the most common cancer among females globally and its toll is rapidly rising in India. Accurate knowledge about prognostic factors could assist oncologists in making correct treatment decisions and acquiring a better understanding of the survival of patients. In patients with hormone receptor-positive, early diagnosis along with socioeconomic factors like education, income, etc., are said to play a vital role. Hence, the present study aimed to analyze the survival pattern depending on hormone receptor status, stages of breast cancer, and socioeconomic status.
Methods: An Ambi directional cohort study was conducted among 300 patients with breast cancer registered and treated in a tertiary care hospital in Dakshina Kannada, India, in the last 3 years. A validated proforma was used to collect data. The post-treatment survival was analyzed depending on their income, family history, staging (clinical & histopathological), and hormone receptor status (HER-2/ER).
Results: The pattern of receptor among these patients showed 45% ER, 43% PR, and 14.3% HER2 positivity. Among the patients, 83% had undergone hormonal therapy as per the receptor status. The overall survival rate of breast cancer patients was found to be 81%. The clinical stage of disease had a statistically significant association with survival using the log-rank test. However, monthly income and hormonal status showed no significance.
Conclusion: A 3-year survival rate was 100% for stage Ⅰ patients, 96.6% for stage Ⅱ, 82.1% for stage Ⅲ, and 40% for stage Ⅳ. Hormone receptor positivity is highly predictive for better prognosis in breast cancer patients.

Full-Text [PDF 204 kb]   (24 Downloads) |   |   Full-Text (HTML)  (18 Views)  
Systematic Review: Original Research | Subject: Gynecology Oncology
Received: 2021/08/31 | Accepted: 2021/09/29 | Published: 2022/01/12

References
1. Breast cancer, https://www.who.int/news-room/fact-sheets/detail/breast-cancer (accessed 1 July 2021).
2. Trends of Breast Cancer in India | Latest Statistics of Breast Cancer India for 2020, https://www.breastcancerindia.net/statistics/trends.html (accessed 1 July 2021).
3. Al-Moundhri MS, Kumar S, Burney IA, et al. Changing trends of breast cancer survival in sultanate of Oman. J Oncol; 2011. Epub ahead of print 2011. [DOI:10.1155/2011/316243] [PMID] [PMCID]
4. Harris JR, Lippman ME, Morrow M, et al. Diseases of the Breast, 5e.
5. Factors affecting survival of women diagnosed with breast cancer in El-Minia Governorate, Egypt - PubMed, https://pubmed.ncbi.nlm.nih.gov/21811654/ (accessed 1 July 2021).
6. Dunnwald LK, Rossing MA, Li CI. Hormone receptor status, tumor characteristics, and prognosis: A prospective cohort of breast cancer patients. Breast Cancer Res; 9. Epub ahead of print 19 January 2007. DOI: 10.1186/bcr1639. [DOI:10.1186/bcr1639] [PMID] [PMCID]
7. Soerjomataram I, Louwman MWJ, Ribot JG, et al. An overview of prognostic factors for long-term survivors of breast cancer. Breast Cancer Res Treat 2008; 107: 309-330. [DOI:10.1007/s10549-007-9556-1] [PMID] [PMCID]
8. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews - NCBI Bookshelf, https://www.ncbi.nlm.nih.gov/books/NBK72103/ (accessed 1 July 2021).
9. Sant M, Allemani C, Santaquilani M, et al. EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary. Eur J Cancer 2009; 45: 931-991. [DOI:10.1016/j.ejca.2008.11.018] [PMID]
10. Esserman LJ, Berry DA, DeMichele A, et al. Pathologic complete response predicts recurrence-free survival more effectively by cancer subset: Results from the I-SPY 1 TRIAL - CALGB 150007/150012, ACRIN 6657. J Clin Oncol 2012; 30: 3242-3249. [DOI:10.1200/JCO.2011.39.2779] [PMID] [PMCID]
11. Gordon NH. Socioeconomic factors and breast cancer in black and white Americans. Cancer Metastasis Rev 2003; 22: 55-65. [DOI:10.1023/A:1022212018158] [PMID]
12. Bradley CJ, Given CW, Roberts C. Race, socioeconomic status, and breast cancer treatment and survival. J Natl Cancer Inst 2002; 94: 490-496. [DOI:10.1093/jnci/94.7.490] [PMID]
13. Socioeconomic status and breast cancer survival in Pakistani women - PubMed, https://pubmed.ncbi.nlm.nih.gov/15518365/ (accessed 1 July 2021). [PMID]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License Journal of Obstetrics, Gynecology and Cancer Research by Farname Inc is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Based on a work at http://jogcr.com/.

© 2022 CC BY-NC 4.0 | Journal of Obstetrics, Gynecology and Cancer Research (JOGCR)

Designed & Developed by : Yektaweb | Piblisher: Farname Inc.