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Volume 7, Issue 5 (September - October 2022)                   J Obstet Gynecol Cancer Res 2022, 7(5): 391-398 | Back to browse issues page

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Shady N W, Farouk H A, Sallam H F. Clinical Outcome of Self-administered Vaginal Isonicotinic Acid Hydrazide (INH) Before T380A Copper Intrauterine Device Insertion in Adolescent and Young Women: A Double-Blind Randomized Controlled Study. J Obstet Gynecol Cancer Res. 2022; 7 (5) :391-398
URL: http://jogcr.com/article-1-526-en.html
1- Department of Obstetrics and Gynecology, Aswan Faculty of Medicine, Aswan University, Aswan Governorate, Egypt , nahlagyn@yahoo.com
2- Mansoura Insurance Hospital, Mansoura, Egypt
3- Department of Obstetrics and Gynecology, Aswan Faculty of Medicine, Aswan University, Aswan Governorate, Egypt
Abstract:   (150 Views)

     Background & Objective: To see if 900 mg of vaginal isonicotinic acid hydrazide (INH) given 12 hours before insertion of a T380A copper intrauterine device (IUD) was more effective than placebo in increasing insertion ease and reducing insertion discomfort in nulliparous ladies.
Materials & Methods: A double-blind, randomized controlled study recruited nulliparous women who wanted to use the Copper IUD for contraception. Women who were WHO-eligible for IUD implantation were recruited and randomly assigned (1:1) to vaginal INH 900 mg or placebo (n=100 in each group), 12 hours before the IUD was placed. The primary endpoint was the ease of insertion for the providers. The number of unsuccessful IUD insertions was also recorded.
Results: The groups had similar baseline characteristics. The ease of insertion score in the INH group was lower than in the placebo group (3 (2-5).5 vs. 6 (3-8); P=0.01), indicating that physicians in the INH group had an easier time inserting the device. The INH group had a reduced mean pain score during the procedure (3.97
±  0.991 vs. 6.42 ±  0.66; P=0.001). In the INH group, two incidences of failed IUD insertion occurred (2%) compared to four cases in the control group (4 percent). 0.594 is the p-value.
Conclusion: Self-administered INH 900 mg vaginally 12 hours before a copper T380A IUD insertion successfully reduced discomfort during insertion and improved women's satisfaction and ease of insertion as measured by physicians in nulliparous teenagers and young ladies.

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Systematic Review: Original Research | Subject: General Gynecology and Pelvic Floor
Received: 2021/10/31 | Accepted: 2021/12/28 | Published: 2022/07/7

1. Lu S, Lin J, Zhang Z, Xiao L, Jiang Z, Chen J, Hu C, Luo S. Alert for non‐respiratory symptoms of coronavirus disease 2019 patients in epidemic period: A case report of familial cluster with three asymptomatic COVID‐19 patients. J Med Virol. 2021;93(1):518-21. [DOI:10.1002/jmv.25776] [PMID]
2. Zeng JH, Liu YX, Yuan J, Wang FX, Wu WB, Li JX, et al. First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. Infection. 2020;48(5):773-7. [DOI:10.1007/s15010-020-01424-5] [PMID] [PMCID]
3. Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514-23. [DOI:10.1016/S0140-6736(20)30154-9]
4. Han C, Duan C, Zhang S, Spiegel B, Shi H, Wang W, Zhang L, Lin R, Liu J, Ding Z, Hou X. Digestive symptoms in COVID-19 patients with mild disease severity: clinical presentation, stool viral RNA testing, and outcomes. Am J Gastroenterol. 2020; 115(6):916-23. [DOI:10.14309/ajg.0000000000000664] [PMID] [PMCID]
5. Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, et al. Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020;5(11):1265-73. [DOI:10.1001/jamacardio.2020.3557] [PMID] [PMCID]
6. Huang L, Zhao P, Tang D, Zhu T, Han R, Zhan C, et . Cardiac involvement in patients recovered from COVID-2019 identified using magnetic resonance imaging. Cardiovasc Imag. 2020;13(11):2330-9. [DOI:10.1016/j.jcmg.2020.05.004] [PMID] [PMCID]
7. Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, et al. Correlation of chest CT and RT-PCR testing for coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology. 2020;296(2):E32-40. [DOI:10.1148/radiol.2020200642] [PMID] [PMCID]
8. Liu D, Li L, Wu X, Zheng D, Wang J, Yang L, et al. Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. AJR Am J Roentgenol. 2020;215(1):127-32. [DOI:10.2214/AJR.20.23072] [PMID]
9. Liu H, Liu F, Li J, Zhang T, Wang D, Lan W. Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children. J Infect. 2020;80(5):e7-13. [DOI:10.1016/j.jinf.2020.03.007] [PMID] [PMCID]
10. Long C, Xu H, Shen Q, Zhang X, Fan B, Wang C, et al. Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT?. Eur J Radiol. 2020;126:108961. [DOI:10.1016/j.ejrad.2020.108961] [PMID] [PMCID]
11. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809-15. [DOI:10.1016/S0140-6736(20)30360-3]
12. Liu W, Wang Q, Zhang Q, Chen L, Chen J, Zhang B, et al. Coronavirus disease 2019 (COVID-19) during pregnancy: a case series.
13. Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, Liu Y, Xiao J, Liu H, Deng D, Chen S. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020;20(5):559-64. [DOI:10.1016/S1473-3099(20)30176-6]
14. Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med. 2020;144(7):799-805. [DOI:10.5858/arpa.2020-0901-SA] [PMID]
15. World Health Organization. Clinical management of severe acute respiratory infection (‎‎ SARI)‎‎ when COVID-19 disease is suspected: interim guidance, 13 March 2020. World Health Organization; 2020. [DOI:10.15557/PiMR.2020.0003]
16. Dashraath P, Wong JL, Lim MX, Lim LM, Li S, Biswas A, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol. 2020;222(6):521-31. [DOI:10.1016/j.ajog.2020.03.021] [PMID] [PMCID]
17. Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9(1):51. [DOI:10.21037/tp.2020.02.06] [PMID] [PMCID]
18. de Souza Santos D, de Oliveira Menezes M, Andreucci CB, Nakamura-Pereira M, Knobel R, et al. Disproportionate impact of coronavirus disease 2019 (COVID-19) among pregnant and postpartum black women in Brazil through structural racism lens. Clin Infect Dis. 2021;72(11):2068-9. [DOI:10.1093/cid/ciaa1066] [PMID] [PMCID]
19. Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID‐19: a systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020;99(7):823-9. [DOI:10.1111/aogs.13867] [PMID] [PMCID]
20. Ashraf MA, Keshavarz P, Hosseinpour P, Erfani A, Roshanshad A, Pourdast A, et al. Coronavirus disease 2019 (COVID-19): a systematic review of pregnancy and the possibility of vertical transmission. J Reprod Infertil. 2020;21(3):157.
21. Blitz MJ, Rochelson B, Minkoff H, Meirowitz N, Prasannan L, London V, et al. Maternal mortality among women with coronavirus disease 2019 admitted to the intensive care unit. Am J Obstet Gynecol. 2020;223(4):595-9. [DOI:10.1016/j.ajog.2020.06.020] [PMID] [PMCID]
22. Cheng SO, Khan S, Alsafi Z. Maternal death in pregnancy due to COVID‐19. Ultrasound Obstet Gynecol. 2020;56(1):122. [DOI:10.1002/uog.22111] [PMID] [PMCID]
23. Hantoushzadeh S, Shamshirsaz AA, Aleyasin A, Seferovic MD, Aski SK, et al. Maternal death due to COVID-19. Am J Obstetrics Gynecol. 2020;223(1):109-e1. [DOI:10.1016/j.ajog.2020.04.030] [PMID] [PMCID]
24. Takemoto ML, Menezes MO, Andreucci CB, Knobel R, Sousa LA, Katz L, et al. Maternal mortality and COVID-19. J Matern Fetal Neonatal Med. 2020:1-7. [DOI:10.1080/14767058.2020.1786056] [PMID]
25. Reinhard G, Noll A, Schlebusch H, Mallmann P, Ruecker AV. Shifts in the TH1/TH2 balance during human pregnancy correlate with apoptotic changes. Biochem Biophys Res Commun. 1998;245(3):933-8. [DOI:10.1006/bbrc.1998.8549] [PMID]
26. Gujski M, Humeniuk E, Bojar I. Current state of knowledge about SARS-CoV-2 and COVID-19 disease in pregnant women. Med Sci Monit. 2020;26:e924725-1. [DOI:10.12659/MSM.924725]

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