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Volume 7, Issue 5 (September - October 2022)                   J Obstet Gynecol Cancer Res 2022, 7(5): 399-404 | Back to browse issues page

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Ahmadi S, Salarifar E, Ahmadi K, Rahimi M, Bahraini M. The Effect of Metformin in Preventing of Superimposed Preeclampsia: a Randomized Clinical Trial. J Obstet Gynecol Cancer Res 2022; 7 (5) :399-404
URL: http://jogcr.com/article-1-544-en.html
1- Department of Gynecology and Obstetrics, School of Medical Sciences, Iran University of Medical Sciences, Tehran, Iran , ahmadishahnaz2005@yahoo.com
2- Department of Gynecology and Obstetrics, School of Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
3- Department of Computer Science, Faculty of Mathematical Sciences, ShahreKord University, ShahreKord, Iran
4- Gynecologist Forensic Expert, Tehran, Iran
Abstract:   (439 Views)

Background & Objective: Preeclampsia is associated with the release of soluble endoglin (sENG) into the maternal circulation. It inhibits sENG secretion, inhibiting the complex I of the mitochondrial electron transport chain. Therefore, using metformin may be helpful in the prevention of preeclampsia. The aim of this study was to evaluate the effect of metformin in preventing superimposed preeclampsia.
Materials & Methods: This single-blind randomized clinical trial was conducted on 60 pregnant women 25-40 years old with chronic hypertension before the 20th week of pregnancy. The patients were randomized and divided into two groups (n=30). The first group received 1000 mg metformin (tablet metformin 500 mg bid), and the second group received a placebo (2 tablets daily). Then the incidence of preeclampsia and intrauterine retardation growth of the fetus were compared in the two groups.
Results: The metformin consumption significantly reduced the incidence of preeclampsia (P=0.04) and intrauterine growth restriction (P=0.035) compared to the control group.
Conclusion: Metformin effectively reduced the incidence of superimposed preeclampsia and related factors in a pregnant patient with chronic hypertension.

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Systematic Review: Original Research | Subject: Obstetrics and Gynecology
Received: 2021/11/12 | Accepted: 2021/12/21 | Published: 2022/07/7

1. Brownfoot FC, Hastie R, Hannan NJ, Cannon P, Tuohey L, Parry LJ, et al. Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction. Am J Obstet Gynecol. 2016;214(3):356-e1. [DOI:10.1016/j.ajog.2015.12.019] [PMID]
2. Gholami H, Fayazi S, Shirshekan M, Motamed N, Tofighi S. Comparison of Serum level of Vitamin D in Pregnant Women with Preeclampsia and a Control Group in Ayatollah Mousavi Hospital in Zanjan. J Obstet Gynecol Cancer Res. 2022;7(4):335-40. [DOI:10.30699/jogcr.7.4.335]
3. Tu'uhevaha J, Tong S, Beard S, Hastie R, Tuohey L, Brownfoot F, et al. Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin. Pregnancy Hypertens. 2014;4(4):287-95. [DOI:10.1016/j.preghy.2014.09.003] [PMID]
4. Obstetricians A. Gynecologists. Hypertension in pregnancy Report of the American college of obstetricians and gynecologists' task force on hypertension in pregnancy Obstet Gynecol. 2013;122(5):1122.
5. Ma'ayeh M, Rood KM, Kniss D, Costantine MM. Novel interventions for the prevention of preeclampsia. Curr Hypertens Rep. 2020;22(2):1-8. [DOI:10.1007/s11906-020-1026-8] [PMID] [PMCID]
6. Espinoza J, Vidaeff A, Pettker C, Simhan H. ACOG practice bulletin no. 202: gestational hypertension and preeclampsia. Obstet Gynecol. 2019;1(133):e1-25.
7. Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS. Williams obstetrics, 24e: Mcgraw-hill New York, NY, USA; 2014.
8. Genest DS, Falcao S, Gutkowska J, Lavoie JL. Impact of exercise training on preeclampsia: potential preventive mechanisms. Hypertension. 2012;60(5):1104-9. [DOI:10.1161/HYPERTENSIONAHA.112.194050] [PMID]
9. Lautatzis M-E, Goulis DG, Vrontakis M. Efficacy and safety of metformin during pregnancy in women with gestational diabetes mellitus or polycystic ovary syndrome: a systematic review. Metab. 2013;62(11):1522-34. [DOI:10.1016/j.metabol.2013.06.006] [PMID]
10. Vazifehkhah S, Bahadori F, Parsania S. Evaluation of Frequency of Maternal and Fetal Complications in Patients with Preeclampsia Admitted to Mothhari Hospital in Urmia in 2019. Studies Med Sci. 2021;31(12):903-11.
11. Safari M, Yzdan Panah B. Prevalence of preeclampsia and its correlated maternal and fetal complications, Emam Sajjad Hospital, Yasuj, 2001. J Shahrekord Univ Med Sci. 2003;5 (2):47-53.
12. Al Yasin A, Aghahoseini M, Khademi A. Comparative study of prenatal care value in incidence of maternal and fetal complication in preeclampsia and eclampsia. Tehran Univ Med J. 2002;60(4):283-8.
13. Ehdaivand F, Rostamnejad M, Iranijam E. A Study of Epidemiological Factors and Complications of Preeclampsia in Alavi Hospital, Ardabil, 2001. J Ardabil Univ Med Sci. 2004;4 (4):25-9.
14. Mesdaghinia E, Talari H, Abedzadeh-Kalahroudi M. Effect of aspirin for prevention of preeclampsia in women with abnormal ultrasonic findings in uterine artery. Feyz Journal of Kashan University of Medical Sciences. 2011;15(2).
15. Kordi M. Sleep quality and preeclampsia: a case-control study. Iran J Obstet Gynecol Infertil. 2015;18 (67):167-8.
16. Nikpour S, Kashany ZA, Parsay S, Mokhtarshahi S, Haghani H. Relationship of vitamin E consumption and preeclampsia/eclampsia in pregnant women. Iran J Nurs. 2008;21(54):105-19.
17. Wang F, Cao G, Yi W, Li L, Cao X. Effect of metformin on a preeclampsia-like mouse model induced by high-fat diet. Biomed Res Int. 2019;2019. [DOI:10.1155/2019/6547019] [PMID] [PMCID]
18. Løvvik TS, Carlsen SM, Salvesen Ø, Steffensen B, Bixo M, Gómez-Real F, et al. Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2019;7(4):256-66. [DOI:10.1016/S2213-8587(19)30002-6]
19. Alqudah A, McKinley MC, McNally R, Graham U, Watson CJ, Lyons TJ, et al. Risk of preeclampsia in women taking metformin: a systematic review and meta‐analysis. Diabet Med. 2018;35(2):160-72. [DOI:10.1111/dme.13523] [PMID]
20. Romero R, Erez O, Hüttemann M, Maymon E, Panaitescu B, Conde-Agudelo A, et al. Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. Am J Obstet Gynecol. 2017;217(3):282-302. [DOI:10.1016/j.ajog.2017.06.003] [PMID] [PMCID]
21. Nascimento IBd, Dienstmann G, Souza MLRd, Fleig R, Hoffmann CBPC, Silva JC. Evaluation of preeclampsia results after use of metformin in gestation: systematic review and meta-analysis. Rev Bras de Ginecol e Obstet. 2018;40:713-21. [DOI:10.1055/s-0038-1675214] [PMID]

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