Write your message
Volume 7, Issue 6 (November - December 2022)                   J Obstet Gynecol Cancer Res 2022, 7(6): 513-517 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hashemi N, Soleimani Z. The Relation Between Trichomonas Vaginalis and Female Infertility: A Meta-Analysis. J Obstet Gynecol Cancer Res. 2022; 7 (6) :513-517
URL: http://jogcr.com/article-1-574-en.html
1- Department of Obstetrics and Gynecology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Department of Obstetrics and Gynecology, Baqiyatallah University of Medical Sciences, Tehran, Iran , z.soleimanii2018@gmail.com
Abstract:   (158 Views)

Background & Objective: The association of Trichomonas vaginalis (T. vaginalis) and infertility is controversial. There is a doubt regarding the relation between T. vaginalis infection and female infertility. This study is the first meta-analysis that investigated the association between T. vaginalis infection and risk of female infertility.
Materials & Methods: Web of Science, PubMed and Scopus were searched using appropriate keywords as major international electronic bibliographic databases up to January 2020. Q-test and I2 statistic were used for evaluating heterogeneity between studies as well as Begg's and Egger's tests for exploring publication. Results were reported by pooled odds ratio (OR) estimate from individual studies by choosing random-effects model.
Results: In total, 650 articles were obtained by initial search until January 2020 with 9779 women. Results of the pooled OR estimates showed a significant association between T. vaginalis and infertility in adjusted studies (OR=1.95; 95% CI: 1.46, 2.43). Based on Begg's and Egger's tests, there was no evidence of publication bias (P=0.532 and P=0.896, respectively).
Conclusion: There was a significant association between T. vaginalis and female infertility. However, more evidence is necessary to prove the potential association of T. vaginalis with an increased risk of female infertility.

     
Systematic Review: Meta-analysis | Subject: Obstetrics and Gynecology
Received: 2021/12/17 | Accepted: 2022/02/11 | Published: 2022/09/9

References
1. Adamson PC, Krupp K, Freeman AH, Klausner JD, Reingold AL, Madhivanan P. Prevalence & correlates of primary infertility among young women in Mysore, India. Indian J Med Res. 2011;134(10):440-6.
2. Kaya OA, Silfeler DB, Kurt RK, Gozukara I, Yengil E, Bayramoglu N. Investigation of the presence of Trichomonas vaginalis in infertile Turkish women. Asian Biomed. 2015;9(5):659-63. [DOI:10.5372/1905-7415.0905.437]
3. World Health Organization. Prevalence and incidence of selected sexually transmitted infections, Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis, and Trichomonas vaginalis: methods and results used by the WHO to generate 2005 estimates. 2011.
4. Mielczarek E, Blaszkowska J. Trichomonas vaginalis: pathogenicity and potential role in human reproductive failure. Infection. 2016;44(4):447-58. [DOI:10.1007/s15010-015-0860-0] [PMID]
5. Tsevat DG, Wiesenfeld HC, Parks C, Peipert JF. Sexually transmitted diseases and infertility. Am J Obstet Gynecol. 2017;216(1):1-9. [DOI:10.1016/j.ajog.2016.08.008] [PMID] [PMCID]
6. Simhan HN, Anderson BL, Krohn MA, Heine RP, de Tejada BM, Landers DV, et al. Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy. Am J Obstet Gynecol. 2007;196(1):59.e1-.e5. [DOI:10.1016/j.ajog.2006.08.035] [PMID]
7. El-Shazly A, El-Naggar H, Soliman M, El-Negeri M, El-Nemr H, Handousa A, et al. A study on Trichomoniasis vaginalis and female infertility. J Egypt Soc Parasitol. 2001;31(2):545-53.
8. Grodstein F, Goldman MB, Cramer DW. Relation of tubal infertility to history of sexually transmitted diseases. Am J Epidemiol. 1993;137(5):577-84. [DOI:10.1093/oxfordjournals.aje.a116711] [PMID]
9. Kildea S, Bowden FJ. Reproductive health, infertility and sexually transmitted infections in Indigenous women in a remote community in the Northern Territory. Aust N Z J Public Health. 2000;24(4):382-6. [DOI:10.1111/j.1467-842X.2000.tb01598.x] [PMID]
10. Sherman KJ, Daling JR, Weiss NS. Sexually transmitted diseases and tubal infertility. Sex Transm Dis. 1987;14(1):12-6. https://doi.org/10.1097/00007435-198701000-00003 [DOI:10.1097/OLQ.0000000000001292] [PMID]
11. El-Shazly AM, El-Naggar HM, Soliman M, El-Negeri M, El-Nemr HE, Handousa AE, et al. A study on Trichomoniasis vaginalis and female infertility. J Egypt Soc Parasitol. 2001;31(2):545-53.
12. Okonofua FE, Ako-Nai KA, Dighitoghi MD. Lower genital tract infections in infertile Nigerian women compared with controls. Genitourin Med. 1995;71(3):163-8. [DOI:10.1136/sti.71.3.163] [PMID] [PMCID]
13. Sherman KJ, Daling JR, Stergachis A, Weiss NS, Foy HM, Wang SP, et al. Sexually transmitted diseases and tubal pregnancy. Sex Transm Dis. 1990;17(3):115-21. [DOI:10.1097/00007435-199007000-00001] [PMID]
14. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264-9. [DOI:10.7326/0003-4819-151-4-200908180-00135] [PMID]
15. Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses Ontario: Ottawa Hospital Research Institute; 2009 [Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
16. Higgins JPT, Thompson SG, Deeks JJ, Altman D. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-60. [DOI:10.1136/bmj.327.7414.557] [PMID] [PMCID]
17. Begg CB, Mazumdar M. Operating characteristics of a rank cor relation test for publication bias. Biometrics. 1994;50(4):1088-101. [DOI:10.2307/2533446]
18. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-88. [DOI:10.1016/0197-2456(86)90046-2]
19. Klinger EV, Kapiga SH, Sam NE, Aboud S, Chen C-Y, Ballard RC, et al. A Community-based study of risk factors for Trichomonas vaginalis infection among women and their male partners in Moshi urban district, northern Tanzania. Sex Transm Dis. 2006;33(12):712-8. [DOI:10.1097/01.olq.0000222667.42207.08] [PMID]
20. Rostami MN, Rashidi BH, Habibi A, Nazari R, Dolati M. Genital infections and reproductive complications associated with Trichomonas vaginalis, Neisseria gonorrhoeae, and Streptococcus agalactiae in women of Qom, central Iran. Int J Reprod Biomed. 2017;15(6):357. [DOI:10.29252/ijrm.15.6.357]
21. Nourollahpour Shiadeh M, Niyyati M, Fallahi S, Rostami A. Human parasitic protozoan infection to infertility: a systematic review. Parasitol Res. 2016;115(2):469-77. [DOI:10.1007/s00436-015-4827-y] [PMID]
22. el-Sharkawy IM, Hamza SM, el-Sayed MK. Correlation between trichomoniasis vaginalis and female infertility. J Egypt Soc Parasitol. 2000;30(1):287-94.

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License Journal of Obstetrics, Gynecology and Cancer Research by Farname Inc is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Based on a work at http://jogcr.com/.

© 2022 CC BY-NC 4.0 | Journal of Obstetrics, Gynecology and Cancer Research (JOGCR)

Designed & Developed by : Yektaweb | Piblisher: Farname Inc.