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Volume 7, Issue 6 (November - December 2022)                   J Obstet Gynecol Cancer Res 2022, 7(6): 518-523 | Back to browse issues page

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Mehrafza M, Raoufi A, Hosseinzadeh E, Pourseify G R, Zare Yousefi T, Shakery T et al . The Effect of Intrauterine Infusion of Plasma Enriched Platelet on Live Birth Rate in Patients with Implantation Failure: A Retrospective Uncontrolled Study. J Obstet Gynecol Cancer Res. 2022; 7 (6) :518-523
URL: http://jogcr.com/article-1-578-en.html
1- Department of Infertility and IVF, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran , marzieh.mehrafza@gmail.com
2- Department of Developmental Biology, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran
3- Department of Embryology, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran
4- Department of Genetics, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran
5- Department of Obstetrics and Gynecology, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran
6- Department of Animal Biology, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran
7- Department of Medicine, Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (150 Views)

Background & Objective: Autologous platelet-rich plasma consists of concentrated autologous plasma and several cytokines and growth factors released by activated platelets in injury and inflammation. There is an increasing trend towards the effectiveness of intrauterine PRP infusion in repeated implantation failure patients. The aim of the present study was to describe the impact of intrauterine platelet-rich plasma infusion on the live birth rate in patients with repeated implantation failure.
Materials & Methods: The present retrospective uncontrolled study was performed on 96 patients with more than two failed intracytoplasmic sperm injection cycles at Mehr medical institute between 2019 and 2021. Forty-eight hours before embryo transfer, patients received 1 mL lympho-platelet-rich plasma through an intrauterine insemination catheter. Patients were evaluated for pregnancy rate. Endometrial preparation for frozen-thawed embryo transfer was performed.
Results: Participants' basal and stimulation characteristics, including gonadotropin dosage, the total number of oocytes, metaphase II oocytes and embryos, endometrial thickness, embryo transfer, quality of transferred embryos, and blastocyst transfer rate were evaluated. A total of 33 and 27 chemical (34.3%) and clinical pregnancies (28.1%) were achieved. Twenty (20.8%) and nineteen (20%) cycles resulted in ongoing pregnancies or live births, respectively.
Conclusion: The current study suggests that platelet-rich plasma infusion 48 hours before frozen-thawed embryo transfer may be a good option for repeated implantation failure patients and results in 20% live birth.

     
Systematic Review: Original Research | Subject: Reproductive Medicine
Received: 2021/12/22 | Accepted: 2022/03/3 | Published: 2022/09/9

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