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Volume 7, Issue 6 (November - December 2022)                   J Obstet Gynecol Cancer Res 2022, 7(6): 536-542 | Back to browse issues page

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Panahi Z, Ghalandarpoor-Attar S N, Shabani A, Shariat M, Ghotbizadeh F, Hantoushzadeh S, et al . Maternal Vitamin D Concentration in Mid-pregnancy and Its Effect on Fetal Thymus Size: A Report from a Tertiary Center in Iran. J Obstet Gynecol Cancer Res. 2022; 7 (6) :536-542
URL: http://jogcr.com/article-1-606-en.html
1- Department of Obstetrics and Gynecology, Vali-e Asr Hospital, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Baqiyatallah Hospital, School of Medicine, Baqyiatallah University of Medical Sciences, Tehran, Iran
3- Department of Obstetrics and Gynecology, Shahid Taleghani Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Fetal and Neonatal Research Center, Vali-e Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
5- Department of Gynecology, Yas Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6- Department of Obstetrics and Gynecology, Baharloo Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran , dr.ghalandarpoor@yahoo.com
Abstract:   (131 Views)

Background & Objective: The thymus gland significantly affects fetal immune system maturation. Additionally, there is a linear association between thymus gland size and its performance. Given the high prevalence of vitamin D deficiency in Iran and scarce studies with conflicting results, subjecting maternal vitamin D concentration effect on fetal thymus, we decided to investigate maternal vitamin D concentration and its relation to fetal thymus size in mid-gestation. This study also aimed to generate a race-specific reference range.
Materials & Methods: We performed a cross-sectional study of ultrasound measurements of the fetal thymus at 18-22 weeks of gestational age in 94 pregnant women and its correlation with maternal serum vitamin D levels from May to July 2021 at the tertiary center of Imam Khomeini Hospital in Tehran, Iran.
Results: The mean values of thymus perimeter, thymus-thoracic ratio, thymus transverse diameter, and thymus area in all participants were 4.18±0.56 cm, 0.37±0.04, 1.56±0.21 cm, and 1.11±0.76 cm2, respectively. There was a trend toward decreased thymus perimeter and transverse thymus diameter with decreasing level of maternal vitamin D. There was also a significant correlation between thymus perimeter and transverse thymus diameter with fetal biometric indices and gestational age. Furthermore, a significant correlation was observed between the thymus perimeter and transverse thymus diameter.
Conclusion: We generated a race-specific nomogram for fetal thymus size in Iranian pregnant women. Moreover, the observed trend toward decreased fetal thymus size with decreasing maternal vitamin D levels requires further prospective investigations. A high prevalence of vitamin D deficiency and low compliance with daily vitamin D intake during pregnancy was also shown, which requires a solution.

Systematic Review: Original Research | Subject: Maternal Fetal Medicine
Received: 2022/01/8 | Accepted: 2022/03/6 | Published: 2022/09/9

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