Document Type : Original Research Article
Authors
- Nasrin Ziamajidi 1
- Nazi Moini 2
- Hiva Danesh 1
- Roghayeh Abbasalipourkabir 1
- Nahid Radnia 3
- Zeinab Barartabar 1
1 Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2 Breast Cancer Research Center, Motamed Cancer Institute, ACERCR, Tehran, Iran
3 Department of Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract
Background & Objective: Breast cancer has the highest incidence of all cancers and the incidence of this disease is increasing rapidly in many countries around the world, including Iran. In this study, some epidemiological and pathological factors have been investigated in breast cancer patients.
Methods: This is a cross-sectional study which contains 476 patients with a confirmed diagnosis of breast cancer, was conducted in Tehran, Dr. Moini Breast Clinic from 2019 to 2021.
Results: The mean age of patients was 50.2±11.40 years, of which 80.9% patients over 40 years. Ductal carcinoma was the most common in terms of histology (81.7%) and most patients are in grade 2 (63.6%). According to hormonal receptors, 73.8% of women had estrogen receptor positive and 68.9% of women had progesterone receptor positive and 18.9% of patients were triple negative. There is a significant relationship between grade and lymph node involvement (P-value=0.00) and also a significant relationship between metastasis with grade (P-value = 0.00 (and metastasis with lymph node involvement (P-value = 0.00) was seen.
Conclusion The results of this study show that breast cancer has a high prevalence in Iranian women in Tehran, mainly seen in the 4th and 5th decades of breast cancer. HER-2 (epidermal growth factor 2 receptor overexpression) and triple negatives were the least subgroups. Considering that diagnosis happens late and about 63.6% of patients are in grade 2, it is necessary to implement programs in the field of screening and prevention in the female population of this province.
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