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Volume 6, Issue 4 (Fall 2021)                   J Obstet Gynecol Cancer Res 2021, 6(4): 174-180 | Back to browse issues page

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Keikha F, Veisian M. The Association between Hypercholesterolemia and Reduced Bone Density in the Femoral Head and Lumbar Spine Using Dual-Energy X-Ray Absorptiometry in Postmenopausal Women. J Obstet Gynecol Cancer Res 2021; 6 (4) :174-180
URL: http://jogcr.com/article-1-338-en.html
1- Tehran medical university -faculty member of obstetric and gynecology department - , keikha.sh@gmail.com
2- department of ob/gyn, Isfahan medical university, beheshti hospital, Isfahan, iran
Abstract:   (590 Views)

Background & Objective: Some studies have suggested the association between the risk of osteoporosis and atherosclerosis. So, we aimed to compare the serum lipid levels of postmenopausal women with reduced bone density to serum lipid levels of those with normal bone density.
Materials & Methods: In this cross-sectional study, all 48-65 year-old women, menopause for more than 1 year prior to the study, who referred to Akbarabadi Hospital, Tehran, Iran, during September 2011-March 2013 were recruited. They underwent bone densitometry using the Dual-Energy X-Ray Absorptiometry Method and were divided into two groups: normal density (control group) and low density (case group). Body mass index (BMI) and waist circumference were measured. After 14 hours, fasting serum levels of lipid, fasting blood sugar (FBS), and HbA1C were checked. Hypercholesterolemia, as low high density lipoprotein (HDL) (<35 mg/dL) and high cholesterol levels (>200 mg/dL), were compared between the groups in addition to low density lipoprotein (LDL) levels.
Results: The data of 241 women were analyzed. The mean±SD levels of serum TC were 192±24.7 and 185±19 mg/dL, in the case and control groups, respectively (P=0.009), and that of serum LDL levels were 112±20.2 and 105±17 g/dL, respectively (P=0.005). There was a significant and negative correlation between the women’s Z-score and their cholesterol level (r=-0.162, P=0.012). Regression results revealed that the following factors significantly affected Z-score: BMI, LDL, TC, and duration of menopause.
Conclusion: Serum LDL and TC levels were higher in menopausal women with reduced bone density, which indicates the relationship between hypercholesterolemia and reduced bone density.

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Systematic Review: Original Research | Subject: Obstetrics and Gynecology
Received: 2021/01/31 | Accepted: 2021/05/22 | Published: 2021/08/11

1. Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. Eur J Rheumatol. 2017;4(1):46-56. [DOI:10.5152/eurjrheum.2016.048]
2. Dempster DW. Osteoporosis and the burden of osteoporosis-related fractures. Am J Manag Care. 2011;17 Suppl 6:S164-9.
3. Qaseem A, Forciea MA, McLean RM, Denberg TD. Treatment of low bone density or osteoporosis to prevent fractures in men and women: a clinical practice guideline update from the American College of Physicians. Ann Intern Med. 2017;166(11):818-39. [DOI:10.7326/M15-1361]
4. Vasikaran S, Eastell R, Bruyère O, Foldes A, Garnero P, Griesmacher A, et al. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int. 2011;22(2):391-420. [DOI:10.1007/s00198-010-1501-1]
5. Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, et al. Clinician's Guide to Prevention and Treatment of Osteoporosis. Osteoporos Int. 2014;25: 2359-81. [DOI:10.1007/s00198-014-2794-2]
6. Tella SH, Gallagher JC. Prevention and treatment of postmenopausal osteoporosis. J Steroid Biochem Mol Biol. 2014;142:155-70. [DOI:10.1016/j.jsbmb.2013.09.008]
7. de Paula FJ, Rosen CJ. Obesity, diabetes mellitus and last but not least, osteoporosis. Arq Bras Endocrinol Metabol. 2010;54(2):150-7. [DOI:10.1590/S0004-27302010000200010]
8. Félix-Redondo FJ, Grau M, Fernández-Bergés D. Cholesterol and cardiovascular disease in the elderly. Facts and gaps. Aging Dis. 2013;4(3):154-69.
9. Chen SJ, Lin CS, Lin CL, Kao CH. Osteoporosis Is Associated With High Risk for Coronary Heart Disease: A Population-Based Cohort Study. Medicine (Baltimore). 2015;94:e1146 [DOI:10.1097/MD.0000000000001146]
10. Yezerska I, Hernández Hernández J, Olmos Martínez J, González Macías J. Dyslipidemia and bone metabolism. A common bond of the osteoporosis and the atherosclerosis? Rev Osteoporos Metabol Miner. 2011;3:41-50.
11. Pirih F, Lu J, Ye F, Bezouglaia O, Atti E, Ascenzi MG, et al. Adverse effects of hyperlipidemia on bone regeneration and strength. J Bone Miner Res. 2012;27(2):309-18. [DOI:10.1002/jbmr.541]
12. You L, Sheng Z-y, Tang C-l, Chen L, Pan L, Chen J-y. High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats. Acta Pharmacol Sin. 2011;32(12):1498-504. [DOI:10.1038/aps.2011.135]
13. Wang Z, Li Y, Zhou F, Piao Z, Hao J. Effects of Statins on Bone Mineral Density and Fracture Risk: A PRISMA-compliant Systematic Review and Meta-Analysis. Medicine (Baltimore). Medicine. 2016 May;95(22).e3042. [DOI:10.1097/MD.0000000000003042]
14. Mandal CC. High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms. Front Endocrinol (Lausanne). Front Endocrinol. 2015;6:165. [DOI:10.3389/fendo.2015.00165]
15. Okayasu M, Nakayachi M, Hayashida C, Ito J, Kaneda T, Masuhara M, et al. Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice because of defect in osteoclastic cell-cell fusion. J Biol Chem. 2012;287(23):19229-41. [DOI:10.1074/jbc.M111.323600]
16. Makovey J, Chen JS, Hayward C, Williams FM, Sambrook PN. Association between serum cholesterol and bone mineral density. Bone. 2009;44(2):208-13. [DOI:10.1016/j.bone.2008.09.020]
17. Ghadiri-Anari A, Mortezaii-Shoroki Z, Modarresi M, Dehghan A. Association of lipid profile with bone mineral density in postmenopausal women in Yazd province. Int J Reprod Biomed (Yazd). 2016;14:597-602. [DOI:10.29252/ijrm.14.9.597]
18. Brownbill RA, Ilich JZ. Lipid profile and bone paradox: higher serum lipids are associated with higher bone mineral density in postmenopausal women. J Women’s Health (Larchmt). 2006;15:261-70. [DOI:10.1089/jwh.2006.15.261]
19. Chen Y, Wang W, Yang L, Chen W, Zhang H. Association between lipid profiles and osteoporosis in postmenopausal women: a meta-analysis. Eur Rev Med Pharmacol Sci. 2018;22(1):1-9.
20. Hmamouchi I, Allali F, Khazzani H, Bennani L, Mansouri LE, Ichchou L, et al. Low bone mineral density is related to atherosclerosis in postmenopausal Moroccan women. BMC Public Health. 2009;9(1):388. [DOI:10.1186/1471-2458-9-388]
21. Jeong TD, Lee W, Choi SE, Kim JS, Kim HK, Bae SJ, et al. Relationship between serum total cholesterol level and serum biochemical bone turnover markers in healthy pre- and postmenopausal women. BioMed research international. 2014;2014. [DOI:10.1155/2014/398397]
22. Tarakida A, Iino K, Abe K, Taniguchi R, Higuchi T, Mizunuma H, et al. Hypercholesterolemia accelerates bone loss in postmenopausal women. Climacteric. 2011;14(1):105-11. [DOI:10.3109/13697137.2010.507888]
23. Ersoy GS, Simsek EE, Vatansever D, Kasikci HO, Keser B, Sakin O. Lipid profile and plasma atherogenic index in postmenopausal osteoporosis. North Clin Istanb. 2017;4:237-41.
24. Solomon DH, Avorn J, Canning CF, Wang PS. Lipid levels and bone mineral density. Am J Med. 2005;118:1414. [DOI:10.1016/j.amjmed.2005.07.031]
25. Sabour H, Norouzi Javidan A, Latifi S, Hadian MR, Emami Razavi SH, Shidfar F, et al. Is lipid profile associated with bone mineral density and bone formation in subjects with spinal cord injury? J Osteoporos. 2014;2014:695014. [DOI:10.1155/2014/695014]
26. Boskey AL, Coleman R. Aging and bone. J Dent Res. 2010;89(12):1333-48. [DOI:10.1177/0022034510377791]
27. Allali F, Maaroufi H, El Aichaoui S, Khazani H, Saoud B, Benyahya B, et al. Influence of parity on bone mineral density and peripheral fracture risk in Moroccan postmenopausal women. Maturitas. 2007;57(4):392-8. [DOI:10.1016/j.maturitas.2007.04.006]
28. Manolagas SC. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. 2010;31(3):266-300. [DOI:10.1210/er.2009-0024]
29. Cao JJ. Effects of obesity on bone metabolism. J Orthop Surg Res. 2011;6(1):30-7. [DOI:10.1186/1749-799X-6-30]
30. Ma L, Oei L, Jiang L, Estrada K, Chen H, Wang Z, et al. Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies. Eur J Epidemiol. 2012;27(5):319-32. [DOI:10.1007/s10654-012-9674-x]

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