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Volume 7, Issue 5 (September - October 2022)                   J Obstet Gynecol Cancer Res 2022, 7(5): 374-381 | Back to browse issues page


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Oluboyo A, Sanami E, Oluboyo B. Evaluation of Selected Trace Elements and Glutathione Peroxidase Levels in Female Infertility. J Obstet Gynecol Cancer Res. 2022; 7 (5) :374-381
URL: http://jogcr.com/article-1-500-en.html
1- Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria , oluboyoao@abuad.edu.ng
2- Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria
Abstract:   (133 Views)

Infertility is an important world-wide reproductive disorder and some couples are being affected everyday as the population increases. The study aimed to evaluate the levels of selected trace elements (zinc, magnesium, selenium) and glutathione peroxidase in female subjects diagnosed with infertility. The study investigated a total of 90 subjects; 25 subjects diagnosed of primary infertility, 25 subjects diagnosed with secondary infertility and 40 apparently healthy individuals which served as the control group within the age range of 20-45years. Samples were obtained from the patients who attended the obstetrics and gynecology department, Federal Medical Centre, Ido-Ekiti, Ekiti State, Nigeria. Zinc (Zn) and selenium (Se) were estimated using atomic absorption spectrophotometer (AAS), magnesium (Mg) was estimated spectrophotometrically, while glutathione peroxidase (GPx) was evaluated using enzyme linked immunosorbent assay (ELISA) technique. Zinc (Zn), magnesium (Mg) and glutathione peroxidase (GPx), were significantly lower (P>0.05) in subjects with infertility in relation to the control subjects, while selenium (Se) was found to be significantly higher (P<0.05) in subjects with infertility compared with control subjects. Selenium (Se) and magnesium (Mg) were significantly lower (P<0.05) in subjects diagnosed with primary infertility compared with subjects diagnosed with secondary infertility. No significant difference (P<0.05) was found in serum zinc (Zn) levels and glutathione peroxidase (GPx) between subjects with primary and secondary infertility. The study concluded that the parameters are useful and should be included in the routine assessment, diagnosis and monitoring of cases of infertility.

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Systematic Review: Original Research | Subject: Reproductive Medicine
Received: 2021/09/20 | Accepted: 2021/12/29 | Published: 2022/07/7

References
1. Greil AL, Blevins KS, McQuillan J. The experience of infertility: A review of recent literature. Sociol Health Illn. 2010;32:140-62. [DOI:10.1111/j.1467-9566.2009.01213.x] [PMID] [PMCID]
2. Anokye R, Acheampong E, Mprah WK, Ope JO, Barivure TN. Psychosocial effects of infertility among couples attending St. Michael's Hospital, Jachie-Pramso in the Ashanti Region of Ghana. BMC Res Notes. 2017;10(1):690. [DOI:10.1186/s13104-017-3008-8] [PMID] [PMCID]
3. Thomas KD, Adeoye O.OO. Biochemical Markers in Seminal Plasma. AJOG. 2015; 65(22): 32-35.
4. Chimbatata NBW, Malimba C. Infertility in sub-Saharan Africa: a Woman's issue for how long? A qualitative review of literature. Open J Soc Sci. 2016;4:96-102. [DOI:10.4236/jss.2016.48012]
5. World Health Organization (WHO). International Classification of Diseases, 11th Revision (ICD-11) Geneva: WHO 2018.
6. World Health Organization (WHO). Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. WHO Bulletin 2013; 33(5):1603-5.
7. Lunenfeld B, Van Steirteghem A. Infertility in the third millennium: implications for the individual, family and society: condensed meeting report from the Bertarelli Foundation's second global conference. Hum Reprod Update. 2004;10:317-326. [DOI:10.1093/humupd/dmh028] [PMID]
8. Cox L, Liu JH. Primary ovarian insufficiency: An update. Int J Women's Health, 2014;6:235-43. [DOI:10.2147/IJWH.S37636] [PMID] [PMCID]
9. Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, et al. EDC-2: the Endocrine Society's second scientific statement on endocrine-disrupting chemicals. Endocrine reviews. 2015;36(6):E1-50. [DOI:10.1210/er.2015-1010] [PMID] [PMCID]
10. Segal TR, Giudice LC. Before the beginning: environmental exposures and reproductive and obstetrical outcomes. Fertility and Sterility 2019;112(4):613-21. [DOI:10.1016/j.fertnstert.2019.08.001] [PMID]
11. Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: An integrative review. J Res Med Sci. 2013;18(2):144-57.
12. Maret W, Sandstead HH. Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol. 2006;20:3-18. [DOI:10.1016/j.jtemb.2006.01.006] [PMID]
13. Butzow JJ, Eichhorn GL. Different susceptibility of DNA and RNA to cleavage by metal ions. Nature. 2007;254:358-9. [DOI:10.1038/254358a0] [PMID]
14. Berg JM, Shi YG. The galvanization of biology: a growing appreciation for the roles of zinc. Science. 2005;271:1081-5. [DOI:10.1126/science.271.5252.1081] [PMID]
15. Favier AE. The role of zinc in reproduction: hormonal mechanisms. Biol Trace Elem Res. 2002;32:363-82. [DOI:10.1007/BF02784623] [PMID]
16. Zago MP, Oteiza PI. The antioxidant properties of zinc: Interactions with iron and antioxidants. Free Radic Biol Med. 2001;31:266-74. [DOI:10.1016/S0891-5849(01)00583-4]
17. Zhang XL, Zhao Y, Chu QQ, Wang ZY, Li HJ, Chi ZH. Zinc modulates high glucose-induced apoptosis by suppressing oxidative stress in renal tubular epithelial cells. Biol Trace Elem Res. 2014;158:259-67. [DOI:10.1007/s12011-014-9922-x] [PMID]
18. Shutterstock. Causes of female infertility. https://www.shutterstock.com/image-vector/vector-poster-causes-female-infertility-illustration-1300286326. Assessed 05/04/2022
19. Gurevich, R. Infertility risk factors In: 12 Potential Signs of a Fertility Problem. Verywell family, 2020. Assessed 05/04/2022. [https://www.verywellfamily.com/symptoms-of-infertility-1960282]
20. Ali Qureshi GA, Memon SA, Memon AB, Ghouri RA, Memon JM. The role of trace elements in female reproduction. Human Repro. 2005;200:219-656.
21. Elin RJ. Magnesium: the fifth but forgotten electrolyte. Am J Clin Path. 2004;102:616-22. [DOI:10.1093/ajcp/102.5.616] [PMID]
22. Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and insulin resistance. Magnes Res. 2004;17(2):126-36.
23. Newhouse IJ, Finstad EW. The effects of magnesium supplementation on exercise performance. Clin J Med. 2000;10:195-200. [DOI:10.1097/00042752-200007000-00008] [PMID]
24. Bohl CH, Volpe SL. Magnesium and exercise. Crit Rev Food Sci Nutri J. 2002;42(5):533-63. [DOI:10.1080/20024091054247] [PMID]
25. Chubanov V, Mittermeier L, Gudermann T. Role of kinase-coupled TRP channels in mineral homeostasis. Pharmacol Ther. 2018;184:159-76. [DOI:10.1016/j.pharmthera.2017.11.003] [PMID]
26. Dechent WJ, Ketteler M. Magnesium basics. Clin Kidney J. 2012;5(Suppl 1):i3-i14. [DOI:10.1093/ndtplus/sfr163] [PMID] [PMCID]
27. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo, R. et al. Characterization of mammalian selenoproteomes. Science. 2003;300:1439-43. [DOI:10.1126/science.1083516] [PMID]
28. Mehdi Y, Hornick JL, Istasse L, Dufrasne I. Selenium in the environment, metabolism and involvement in body functions. Molecules. 2013; 18:3292-3311. [DOI:10.3390/molecules18033292] [PMID] [PMCID]
29. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG. Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science. 2000;179:588-90. [DOI:10.1126/science.179.4073.588] [PMID]
30. Patil MC, Tatone C, Delle MS, Marci R, Caserta D, Colonna R. et al. Antioxidant enzymatic defenses in humanfollicular fluid: characterization and age-dependent changes. Mol Hum Reprod. 2010;9: 639-43. [DOI:10.1093/molehr/gag090] [PMID]
31. Lawrence AJ, Khan T. Quantification of Airborne Particulate and Associated Toxic Heavy Metals in Urban Indoor Environment and Allied Health Effects. InMeasurement, analysis and remediation of environmental pollutants 2020 (pp. 7-58). Springer, Singapore. [DOI:10.1007/978-981-15-0540-9_2] [PMCID]
32. Tietz NW. Clinical Guide to Laboratory Tests. In: Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. St. Louis, Mo: Elsevier Saunders. 2010;35:225-9.
33. Jacobson GA, Narkowicz C, Tong YC, Peterson GM. Plasma glutathione peroxidase by ELISA and relationship to selenium level. Clinica Chimica Acta. 2006;369(1):100-3. [DOI:10.1016/j.cca.2006.01.007] [PMID]
34. Slade P, O'Neill C, Simpson AJ, Lashen H. The relationship between perceived stigma, disclosure patterns, support and distress in new attendees at an infertility clinic. Hum Reprod. 2007;22:2309-17. [DOI:10.1093/humrep/dem115] [PMID]
35. Jameson S. Zinc deficiency in malabsorption states. A cause of infertility. Acta medical Scand. 2017;5(39):38-49. [DOI:10.1111/j.0954-6820.1976.tb12825.x] [PMID]
36. Zachara B, Dobrzynski W, Trafikowska U, Szymanski W. Bloodselenium and glutathione peroxidases in miscarriage. Br J Obstet Gynaecol. 2016;108:244-7. https://doi.org/10.1111/j.1471-0528.2001.00030.x [DOI:10.1016/S0306-5456(00)00030-9] [PMID]
37. Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril. 2005;79: 829-43. [DOI:10.1016/S0015-0282(02)04948-8]
38. Agarwal A, Allamaneni SS, Role of free radicals in female reproductive diseases and assisted reproduction. Reprod Biomed. 2008;9:338-47. [DOI:10.1016/S1472-6483(10)62151-7]
39. Adeoye O, Olawumi J, Opeyemi A, Christiania O. Review on the role of glutathione on oxidative stress and infertility. JBRA Assist Reprod. 2018;22(1):61-6. [DOI:10.5935/1518-0557.20180003] [PMID] [PMCID]
40. Soltani N, Keshavarz M, Minaii B, Mirershadi F, Asl SZ, Dehpour AR. Effects of administration of oral magnesium on plasma glucose andpathological changes in the aorta and pancreas of diabetic rats. Clin Exp Pharmacol Physiol. 2005;32:604-10. [DOI:10.1111/j.0305-1870.2005.04238.x] [PMID]
41. Paszkowski T, Traub AI, Robinson SY, McMaster D. Selenium dependent glutathione peroxidase activity in human follicular fluid. Clin Chim Acta. 2015;236:173-80. [DOI:10.1016/0009-8981(95)98130-9]
42. Grieger JA, Grzeskowiak LE, Wilson RL, Bianco-Miotto T, Leemaqz SY, Jankovic-Karasoulos T, et al. Maternal selenium, copper and zinc concentrations in early pregnancy, and the association with fertility. Nutrients. 2019;11(7):1609. [DOI:10.3390/nu11071609] [PMID] [PMCID]
43. Edassery SL, Shatavi SV, Kunkel JP, Hauer C, Brucker C, Penumatsa K, et al. Autoantigens in ovarian autoimmunity associated with unexplained infertility and premature ovarian failure. Fertil Steril. 2010;94:2636-41. [DOI:10.1016/j.fertnstert.2010.04.012] [PMID] [PMCID]
44. Pieczyńska J, Grajeta H. The role of selenium in human conception and pregnancy. J Trace Elem Med Biol. 2015;29:31-8. [DOI:10.1016/j.jtemb.2014.07.003] [PMID]
45. Oluboyo AO, Adijeh RU, Onyenekwe CC, Oluboyo BO, Mbaeri TU, Odiegwu CN. et al. Relationship between serum levels of testosterone, zinc and selenium in infertile males attending fertility clinic in Nnewi, South east Nigeria. Afr J Med and Medical Sci. 2012;41:514.
46. Howard JMC, Davies S, Hunnisett A. Red cell magnesium and glutathione peroxidase in infertile women-effects of oral supplementation with magnesium and selenium. Magnes Res. 2018;7(1):49-57.

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