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Volume 7, Issue 5 (September - October 2022)                   J Obstet Gynecol Cancer Res 2022, 7(5): 405-413 | Back to browse issues page


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Pouryasin M, Mousavi A, Pakravesh J, Zare Kamel D, Nooriardabili S, Khodadad S, et al . The Prevalence of HPV and non-HPV STIs Among Iranian Women and Assessment of the HPV/non-HPV STIs Co-infection on Cervical Cell Changes. J Obstet Gynecol Cancer Res. 2022; 7 (5) :405-413
URL: http://jogcr.com/article-1-502-en.html
1- Department of Molecular Diagnosis, Armin Pathobiology and Genetics Laboratory, Tehran, Iran
2- Department of Gynecology-Oncology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran , azamsadat_mousavi@yahoo.com
3- Department of IVF, Aban Hospital, Tehran, Iran
4- Department of Obstetrics and Gynecology, Atieh Hospital, Tehran, Iran
5- Department of Gynecology-Oncology, Erfan Hospital, Tehran, Iran
6- Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran
7- Department of Pathology, Armin Pathobiology and Genetics Laboratory, Tehran, Iran
Abstract:   (128 Views)

Background & Objective: Persistent infection with some types of Human papillomavirus (HPV), which are high-risk genotypes, can lead the patients toward cervical cancer and, finally, death. Recent studies showed HPV co-infection with non-HPV sexually transmitted infections (non-HPV STIs) could increase the persistency rate of HPV infections. This study aimed to estimate the prevalence of STIs and assess the association of HPV/non-HPV STIs co-infection on cervical cell changes based on cytological findings.
Materials & Methods: In this cross-sectional study, in addition to the routine cervical screening, including HPV testing and cytological assessment, non-HPV STI testing was performed on 1065 Iranian women. To assess the HPV and non-HPV STIs, commercial kits were used.
Results: 964 (90.5%) women had normal cytology (NILM) results. The overall prevalence of HPV and non-HPV STIs were 39.1% and 68.5%, respectively. HPV-53 (6.5%), -16 (6.1%) and -31 (5.5%) were found as the most prevalent genotypes. Ureaplasma Parvum (UP) (42.7%), Group B Streptococcus (GBS) (23.7%), Candida Species (CS) (23.6%), Ureaplasma Urealyticum (UU) (9.6%), and Mycoplasma Hominis (MH) (7.1%) were found as the most prevalent non-HPV STIs. The co-infection of HPV with GBS played an important role in developing the cervical lesion (P<0.05).
Conclusion: In the present study, the STIs, including HPV, UP, GBS, CS, UU, and MH, were prevalent among the study participant, and it was found that the HPV/GBS co-infection played a significant role in the development of LSIL or worse cytological grades. To clarify this issue, further studies will be conducted.

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Systematic Review: Original Research | Subject: Gynecology Oncology
Received: 2021/09/21 | Accepted: 2021/12/25 | Published: 2022/07/7

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