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Volume 7, Issue 5 (September - October 2022)                   J Obstet Gynecol Cancer Res 2022, 7(5): 414-421 | Back to browse issues page


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Bouzari Z, Mohammadi T, Ranaei M, Hajian-Taliki K, Ghanbarpour A. Association Between Gestational Diabetes History with Endometrial Hyperplasia and Cancer. J Obstet Gynecol Cancer Res. 2022; 7 (5) :414-421
URL: http://jogcr.com/article-1-555-en.html
1- Infertility and Reproductive Health Research Center, Health Research Institute and Department of Obstetrics and Gynecology, Babol University of Medical Sciences, Babol, Iran
2- Student Committee Research, Babol University of Medical Sciences, Babol, Iran
3- Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
4- Infertility and Reproductive Health Research Center, Health Research Institute and Department of Obstetrics and Gynecology, Babol University of Medical Sciences, Babol, Iran , dr_ghanbarpour@yahoo.com
Abstract:   (112 Views)

Background & Objective: Gestational diabetes mellitus (GDM) is also defined as a metabolic disease associated with relative insulin resistance during pregnancy, and elevated circulating insulin may increase the risk of EH and EC development. This study aimed to investigate the association between GDM and the incidence of EH and EC.
Materials & Methods: We conducted a retrospective case-control study, including 300 women with abnormal uterine bleeding (AUB) referred to Ayatollah Rouhani Hospital in Babol. Cases (n=152) were patients with HC and EC based on medical records, and the controls (n=148) were individuals without HC and EC. The groups were compared according to demographic information, GDM or diabetes mellitus (DM) history, and body mass index (BMI). The Chi-square, independent t-test, and logistic regression analyses were performed to compare groups.
Results: Of 300 women studied, 72 people (24.1%) had a GDM history, and 64 people had a diabetes mellitus history. There was a significant difference between the incidence of EC and EH with GDM (P=0.001). Both GDM and DM were associated with the increased EC (OR: 17.98, 95% CI: 6.73-48.08, and OR: 1.84, 95% CI: 1.26-2.68, respectively). GDM was also associated with the increased risk of EH (OR: 6.68, 95% CI: 2.77-16.10), whereas diabetes mellitus had not a significant role in the increased risk of EH (P=0.14).
Conclusion: This study indicated that a GDM history is significantly associated with HC and EC. Therefore, to prevent and control these two complications in the future, management and monitoring of diabetes during pregnancy should be considered.

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Systematic Review: Original Research | Subject: Obstetrics and Gynecology
Received: 2021/11/21 | Accepted: 2022/02/5 | Published: 2022/07/7

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