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Sun, Aug 14, 2022
[Archive]
Volume 7, Issue 5 (September - October 2022)
J Obstet Gynecol Cancer Res 2022, 7(5): 429-436 |
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Nouri B, Alemi M, Baghestani A R. The Effect of Laparoscopic Radical Surgery for Endometriosis on Serum Levels of Lipid Profile and Vitamin D. J Obstet Gynecol Cancer Res. 2022; 7 (5) :429-436
URL: http://jogcr.com/article-1-559-en.html
URL: http://jogcr.com/article-1-559-en.html
1- The Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran , nouri@sbmu.com
2- Department of Obstetrics and Gynecology, University of Shahid Beheshti, Shohaday-e Tajrish Hospital, Tehran, Iran
3- Physiotherapy Research Center, Department of Biostatics, Faculty of Paramedical Sciences, ShahidBeheshti University of Medical Sciences, Tehran, Iran
2- Department of Obstetrics and Gynecology, University of Shahid Beheshti, Shohaday-e Tajrish Hospital, Tehran, Iran
3- Physiotherapy Research Center, Department of Biostatics, Faculty of Paramedical Sciences, ShahidBeheshti University of Medical Sciences, Tehran, Iran
Abstract: (131 Views)
Background & Objective: Endometriosis is associated with the increased risk of coronary heart disease and immune alterations, which may be attributed to the altered lipid profile and decreased serum level of 25–hydroxyl vitamin D (25(OH)D). The present study aimed to evaluate the effect of radical laparoscopic surgery of endometriosis on serum lipid profile and 25(OH)D.
Materials & Methods: This cross-sectional study was performed on 47 women aged 15 to 45, with body mass index <30kg/m2, who were referred to Shohaday-eTajrish Hospital, from May 2018 until Jan 2020, for surgical treatment of endometriosis and did not have a systemic disease and did not use oral contraceptives and/or other hormonal therapies three months before surgery were enrolled into the study. The serum lipid profile and 25(OH)D levels of patients two months after surgery were compared with presurgical levels. The results were analyzed by using paired t-test.
Results: A total of 47 patients completed the study (mean age: 32.8±7.5years). About half had no pregnancies (49.1%). Comparing the serum lipid profile of patients before and two months after surgery showed a significant decrease in triglyceride from 108.4±46.2 to 86.4±51.1 mg/dL (P=0.001), ], total cholesterol from 172.5±26.5 to 160.0±28.3mg/dl (P=0.002), and low-density lipoprotein levels from 97±28.3 to 89.8±26.1 mg/dL (P=.003); however, high-density lipoprotein and 25(OH)D levels did not show a significant difference (P>0.05).
Conclusion: the results of the current study showed that laparoscopic resection of endometriotic lesions resulted in a significant reduction of the unfavorable lipid profile after two months, but not 25(OH)D levels.
Systematic Review: Original Research |
Subject:
Gynecology Oncology
Received: 2021/11/27 | Accepted: 2021/12/27 | Published: 2022/07/7
Received: 2021/11/27 | Accepted: 2021/12/27 | Published: 2022/07/7
References
1. Sheikhvatan M, Chaichian S, Moazzami B. A Systematic Review and Bioinformatics Study on Genes and micro-RNAs Involving the Transformation of Endometriosis into Ovarian Cancer. Microrna. 2020;9(2):101-11. [DOI:10.2174/2211536608666190917152104] [PMID] [PMCID]
2. Giudice LC. Endometriosis. N Engl J Med. 2010;362(25):2389-98. [DOI:10.1056/NEJMcp1000274] [PMID] [PMCID]
3. Acién P, Velasco I. Endometriosis: a disease that remains enigmatic. Obstet Gynecol Int. 2013;2013. [DOI:10.1155/2013/242149] [PMID] [PMCID]
4. Nouri, B., Amini, F.G., Arab, M. et al. Comparison of the Outcomes of Direct Trocar Insertion with Modified Open Entry in Laparoscopic Surgery. Indian J Gynecol Oncolog. 2021;19(4):1-5. [DOI:10.1007/s40944-021-00576-y]
5. Mehedintu C, Plotogea M, Ionescu S, Antonovici M. Endometriosis still a challenge. J Med Life. 2014;7(3):349.
6. Herington JL, Bruner-Tran KL, Lucas JA, Osteen KG. Immune interactions in endometriosis. Expert Rev Clin Immunol. 2011;7(5):611-26. [DOI:10.1586/eci.11.53] [PMID] [PMCID]
7. Dutta M, Anitha M, Smith PB, Chiaro CR, Maan M, Chaudhury K, et al. Metabolomics reveals altered lipid metabolism in a mouse model of endometriosis. J Proteome Res. 2016;15(8):2626-33. [DOI:10.1021/acs.jproteome.6b00197] [PMID]
8. Melo AS, Rosa-e-Silva JC, de Sá Rosa ACJ, Poli-Neto OB, Ferriani RA, Vieira CS. Unfavorable lipid profile in women with endometriosis. Fertil Steril. 2010;93(7):2433-6. [DOI:10.1016/j.fertnstert.2009.08.043] [PMID]
9. Almassinokiani F, Mehdizadehkashi A, Amirkhani J, Akbari P, Tahermanesh K, Soheilipour F, et al. Comparing the Serum Lipid Profile Levels in Women Suffering From Endometriosis With Healthy Women. Minim Invasive Surg. 2014;3(3):e19818.
10. Mu F, Rich-Edwards J, Rimm EB, Spiegelman D, Missmer SA. Endometriosis and risk of coronary heart disease. Circ Cardiovasc Qual Outcomes. 2016;9(3):257-64. [DOI:10.1161/CIRCOUTCOMES.115.002224] [PMID] [PMCID]
11. Nouri B, Baghestani AR, Pooransari P. Evening Primrose versus Misoprostol for Cervical Dilatation before Gynecologic Surgeries; a Double-blind Randomized Clinical Trial. J Obstet Gynecol Cancer Res. 2021;6(2):87-94. [DOI:10.30699/jogcr.6.2.87]
12. Almassinokiani F, Mehdizadeh A, Sariri E, Rezaei M, Almasi A, Akbari H, et al. Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis. J Exp Clin Med. 2013;19:534. [DOI:10.12659/MSM.883967] [PMID] [PMCID]
13. Habibi AH, Alizadeh E, Hashemi N, Razmeh S, Mansuri SS, Ghurchian Z, et al. Atherosclerosis in patients with endometriosis. Urogynaecologia. 2019;31(1). [DOI:10.4081/uij.2019.214]
14. Cho M-C, Kim JH, Jung MH, Cho IA, Jo HC, Shin JK, et al. analysis of vitamin D-binding protein (VDBP) gene polymorphisms in Korean women with and without endometriosis. Clin Exp Reprod Med. 2019;46(3):132. [DOI:10.5653/cerm.2019.00122] [PMID] [PMCID]
15. Miyashita M, Koga K, Izumi G, Sue F, Makabe T, Taguchi A, et al. Effects of 1, 25-dihydroxy vitamin D3 on endometriosis. J Clin Endocrinol Metab. 2016;101(6):2371-9. [DOI:10.1210/jc.2016-1515] [PMID]
16. Abbas MA, Taha MO, Disi AM, Shomaf M. Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis. Eur J Pharmacol. 2013;715(1-3):72-5. [DOI:10.1016/j.ejphar.2013.06.016] [PMID]
17. Hidaka T, Nakashima A, Hashimoto Y, Saito S. Effects of laparoscopic radical surgery for deep endometriosis on endometriosis-related pelvic pain. Minim Invasive Ther Allied Technol. 2012;21(5):355-61. [DOI:10.3109/13645706.2011.617758] [PMID]
18. Kelishadi R, Poursafa P. A review on the genetic, environmental, and lifestyle aspects of the early-life origins of cardiovascular disease. Curr Probl Pediatr Adolesc Health Care. 2014;44(3):54-72. [DOI:10.1016/j.cppeds.2013.12.005] [PMID]
19. Sokalska A, Anderson M, Villanueva J, Ortega I, Bruner-Tran KL, Osteen KG, et al. Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis. J Clin Endocrinol Metab. 2013;98(3):E463-E71. [DOI:10.1210/jc.2012-3402] [PMID] [PMCID]
20. Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, et al. Statins inhibit monocyte chemotactic protein 1 expression in endometriosis. Reprod Sci. 2012;19(6):572-9. [DOI:10.1177/1933719111430998] [PMID] [PMCID]
21. Rolla E. Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment. F1000res. 2019;8. [DOI:10.12688/f1000research.14817.1] [PMID] [PMCID]
22. Monsanto SP, Edwards AK, Zhou J, Nagarkatti P, Nagarkatti M, Young SL, et al. Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients. Fertil Steril. 2016;105(4):968-77. e5. [DOI:10.1016/j.fertnstert.2015.11.047] [PMID] [PMCID]
23. Zanelotti A, DeCherney AH. Surgery and endometriosis. Clin Obstet Gynecol. 2017;60(3):477. [DOI:10.1097/GRF.0000000000000291] [PMID] [PMCID]
24. Sarbazi F, Akbari E, Karimi A, Nouri B, Noori Ardebili S. The Clinical Outcome of Laparoscopic Surgery for Endometriosis on Pain, Ovarian Reserve, and Cancer Antigen 125 (CA-125): A Cohort Study. Int J Fertil Steril. 2021;15(4):275-9.
25. Akyol A, Şimşek M, İlhan R, Can B, Baspinar M, Akyol H, et al. Efficacies of vitamin D and omega-3 polyunsaturated fatty acids on experimental endometriosis. Taiwan J Obstet Gynecol. 2016;55(6):835-9. [DOI:10.1016/j.tjog.2015.06.018] [PMID]
26. Harris HR, Chavarro JE, Malspeis S, Willett WC, Missmer SA. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol. 2013;177(5):420-30. [DOI:10.1093/aje/kws247] [PMID] [PMCID]
27. Hoorsan H, Mirmiran P, Chaichian S, Moradi Y, Akhlaghdoust M, Hoorsan R, et al. diet and risk of endometriosis: A systematic review and meta-analysis study. Iran Red Crescent Med J. 2017;19(9). [DOI:10.5812/ircmj.41248]
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Journal of Obstetrics, Gynecology and Cancer Research by Farname Inc is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Based on a work at http://jogcr.com/. |
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Journal of Obstetrics, Gynecology and Cancer Research by Farname Inc is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Based on a work at http://jogcr.com/.
